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Association of Basal Forebrain Volume with Amyloid, Tau, and Cognition in Alzheimer's Disease

Authors
 Han Soo Yoo  ;  Han-Kyeol Kim  ;  Jae-Hoon Lee  ;  Joong-Hyun Chun  ;  Hye Sun Lee  ;  Michel J Grothe  ;  Stefan Teipel  ;  Enrica Cavedo  ;  Andrea Vergallo  ;  Harald Hampel  ;  Young Hoon Ryu  ;  Hanna Cho  ;  Chul Hyoung Lyoo 
Citation
 JOURNAL OF ALZHEIMERS DISEASE, Vol.99(1) : 145-159, 2024-04 
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
ISSN
 1387-2877 
Issue Date
2024-04
MeSH
Aged ; Aged, 80 and over ; Alzheimer Disease* / diagnostic imaging ; Alzheimer Disease* / metabolism ; Alzheimer Disease* / pathology ; Amyloid beta-Peptides* / metabolism ; Basal Forebrain* / diagnostic imaging ; Basal Forebrain* / metabolism ; Basal Forebrain* / pathology ; Cognition* / physiology ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging* ; Male ; Middle Aged ; Neuropsychological Tests ; Positron-Emission Tomography* ; Retrospective Studies ; tau Proteins* / metabolism
Keywords
Alzheimer’s disease ; amyloid-beta ; basal forebrain ; cognition ; tau
Abstract
Background: Degeneration of cholinergic basal forebrain (BF) neurons characterizes Alzheimer's disease (AD). However, what role the BF plays in the dynamics of AD pathophysiology has not been investigated precisely.,Objective: To investigate the baseline and longitudinal roles of BF along with core neuropathologies in AD.,Methods: In this retrospective cohort study, we enrolled 113 subjects (38 amyloid [A beta]-negative cognitively unimpaired, 6 A beta-positive cognitively unimpaired, 39 with prodromal AD, and 30 with AD dementia) who performed brain MRI for BF volume and cortical thickness, F-18-florbetaben PET for A beta, F-18-flortaucipir PET for tau, and detailed cognitive testing longitudinally. We investigated the baseline and longitudinal association of BF volume with A beta and tau standardized uptake value ratio and cognition.,Results: Cross-sectionally, lower BF volume was not independently associated with higher cortical A beta, but it was associated with tau burden. Tau burden in the orbitofrontal, insular, lateral temporal, inferior temporo-occipital, and anterior cingulate cortices were associated with progressive BF atrophy. Lower BF volume was associated with faster A beta accumulation, mainly in the prefrontal, anterior temporal, cingulate, and medial occipital cortices. BF volume was associated with progressive decline in language and memory functions regardless of baseline A beta and tau burden.,Conclusions: Tau deposition affected progressive BF atrophy, which in turn accelerated amyloid deposition, leading to a vicious cycle. Also, lower baseline BF volume independently predicted deterioration in cognitive function.,
Full Text
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad230975
DOI
10.3233/JAD-230975
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Han kyeol(김한결) ORCID logo https://orcid.org/0000-0002-7650-6708
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Chun, Joong-Hyun(전중현) ORCID logo https://orcid.org/0000-0002-9665-7829
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200893
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