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Arterial Stiffness Predicts the Outcome of Endovascular Treatment in Patients with Acute Ischemic Stroke

Authors
 Minho Han  ;  Haram Joo  ;  Hyungwoo Lee  ;  JoonNyung Heo 1  ;  Jae Wook Jung 1  ;  Young Dae Kim  ;  Eunjeong Park  ;  Hyo Suk Nam 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.13(14) : 4198, 2024-07 
Journal Title
JOURNAL OF CLINICAL MEDICINE
Issue Date
2024-07
Keywords
arterial stiffness ; endovascular treatment ; ischemic stroke ; outcome
Abstract
Background: The association between arterial stiffness and outcome after endovascular treatment (EVT) is unknown. This study investigated whether arterial stiffness predicts post-EVT outcome in patients with acute ischemic stroke. Methods: This retrospective and observational cohort study included consecutive patients treated with EVT for acute ischemic stroke from June 2020 to November 2022. Arterial stiffness was assessed by brachial-ankle pulse wave velocity. Poor functional outcome was defined as a modified Rankin Scale score >= 3 at 3 months. Results: The mean age of patients included in this study was 71.9 +/- 11.8 years, and 57.3% were men. Poor functional outcome was present in 46.8%. Multivariable logistic regression analysis showed that arterial stiffness was independently associated with poor functional outcome (odds ratio 8.640, 95% confidence interval [CI] 1.581-47.228) after adjusting for age, initial stroke severity, hypertension, atrial fibrillation, device pass number, and successful recanalization. A nomogram based on the multivariable statistic model showed a better prediction of poor functional outcome compared to classic risk factor models without arterial stiffness (net reclassification improvement 0.529, 95% CI 0.186-0.873; integrated discrimination improvement 0.046, 95% CI 0.009-0.083). Conclusions: We found that arterial stiffness was an independent predictor of poor functional outcome in patients treated with EVT following acute ischemic stroke.
Files in This Item:
T202404862.pdf Download
DOI
39064237
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Park, Eunjeong(박은정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200376
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