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Poor Mobilization-Associated Factors in Autologous Hematopoietic Stem Cell Harvest

Authors
 Won Kee Ahn  ;  Hyun-Jun Nam  ;  Hae Won Lee  ;  Seungmin Hahn  ;  Jung Woo Han  ;  Chuhl Joo Lyu  ;  Sinyoung Kim  ;  Soon Sung Kwon  ;  Haerim Chung  ;  Jin Seok Kim  ;  June-Won Cheong  ;  Kyung-A Lee 
Citation
 CANCERS, Vol.16(10) : 1821, 2024-05 
Journal Title
CANCERS
Issue Date
2024-05
Keywords
peripheral blood stem cell harvest ; hematologic malignancies ; non-hematologic malignancies ; plerixafor ; poor mobilization
Abstract
Peripheral blood stem cell transplantation (PBSCT) is an important therapeutic measure for both hematologic and non-hematologic diseases. For PBSCT to be successful, sufficient CD34+ cells need to be mobilized and harvested. Although risk factors associated with poor mobilization in patients with hematologic diseases have been reported, studies of patients with non-hematologic diseases and those receiving plerixafor are rare. To identify factors associated with poor mobilization, data from autologous PBSC harvest (PBSCH) in 491 patients were retrospectively collected and analyzed. A multivariate analysis revealed that in patients with a hematologic disease, an age older than 60 years (odds ratio [OR] 1.655, 95% confidence interval [CI] 1.049–2.611, p = 0.008), the use of myelotoxic agents (OR 4.384, 95% CI 2.681–7.168, p < 0.001), and a low platelet count (OR 2.106, 95% CI 1.205–3.682, p = 0.009) were associated with poor mobilization. In patients with non-hematologic diseases, a history of radiation on the pelvis/spine was the sole associated factor (OR 12.200, 95% CI 1.934–76.956, p = 0.008). Among the group of patients who received plerixafor, poor mobilization was observed in 19 patients (19/134, 14.2%) and a difference in the mobilization regimen was noted among the good mobilization group. These results show that the risk factors for poor mobilization in patients with non-hematologic diseases and those receiving plerixafor differ from those in patients with hematologic diseases; as such, non-hematologic patients require special consideration to enable successful PBSCH.
Files in This Item:
T202402997.pdf Download
DOI
10.3390/cancers16101821
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sin Young(김신영) ORCID logo https://orcid.org/0000-0002-2609-8945
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Ahn, Won Kee(안원기) ORCID logo https://orcid.org/0000-0003-3668-7396
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
Chung, Hae Rim(정해림) ORCID logo https://orcid.org/0000-0002-7926-9285
Hahn, Seung Min(한승민) ORCID logo https://orcid.org/0000-0001-9832-6380
Han, Jung Woo(한정우) ORCID logo https://orcid.org/0000-0001-8936-1205
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199263
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