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Poor Mobilization-Associated Factors in Autologous Hematopoietic Stem Cell Harvest
DC Field | Value | Language |
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dc.contributor.author | 김신영 | - |
dc.contributor.author | 김진석 | - |
dc.contributor.author | 안원기 | - |
dc.contributor.author | 유철주 | - |
dc.contributor.author | 이경아 | - |
dc.contributor.author | 정준원 | - |
dc.contributor.author | 정해림 | - |
dc.contributor.author | 한승민 | - |
dc.contributor.author | 한정우 | - |
dc.date.accessioned | 2024-05-23T03:35:27Z | - |
dc.date.available | 2024-05-23T03:35:27Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199263 | - |
dc.description.abstract | Peripheral blood stem cell transplantation (PBSCT) is an important therapeutic measure for both hematologic and non-hematologic diseases. For PBSCT to be successful, sufficient CD34+ cells need to be mobilized and harvested. Although risk factors associated with poor mobilization in patients with hematologic diseases have been reported, studies of patients with non-hematologic diseases and those receiving plerixafor are rare. To identify factors associated with poor mobilization, data from autologous PBSC harvest (PBSCH) in 491 patients were retrospectively collected and analyzed. A multivariate analysis revealed that in patients with a hematologic disease, an age older than 60 years (odds ratio [OR] 1.655, 95% confidence interval [CI] 1.049–2.611, p = 0.008), the use of myelotoxic agents (OR 4.384, 95% CI 2.681–7.168, p < 0.001), and a low platelet count (OR 2.106, 95% CI 1.205–3.682, p = 0.009) were associated with poor mobilization. In patients with non-hematologic diseases, a history of radiation on the pelvis/spine was the sole associated factor (OR 12.200, 95% CI 1.934–76.956, p = 0.008). Among the group of patients who received plerixafor, poor mobilization was observed in 19 patients (19/134, 14.2%) and a difference in the mobilization regimen was noted among the good mobilization group. These results show that the risk factors for poor mobilization in patients with non-hematologic diseases and those receiving plerixafor differ from those in patients with hematologic diseases; as such, non-hematologic patients require special consideration to enable successful PBSCH. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Poor Mobilization-Associated Factors in Autologous Hematopoietic Stem Cell Harvest | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Won Kee Ahn | - |
dc.contributor.googleauthor | Hyun-Jun Nam | - |
dc.contributor.googleauthor | Hae Won Lee | - |
dc.contributor.googleauthor | Seungmin Hahn | - |
dc.contributor.googleauthor | Jung Woo Han | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.contributor.googleauthor | Sinyoung Kim | - |
dc.contributor.googleauthor | Soon Sung Kwon | - |
dc.contributor.googleauthor | Haerim Chung | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Kyung-A Lee | - |
dc.identifier.doi | 10.3390/cancers16101821 | - |
dc.contributor.localId | A00675 | - |
dc.contributor.localId | A01017 | - |
dc.contributor.localId | A05357 | - |
dc.contributor.localId | A02524 | - |
dc.contributor.localId | A02647 | - |
dc.contributor.localId | A03729 | - |
dc.contributor.localId | A04674 | - |
dc.contributor.localId | A04299 | - |
dc.contributor.localId | A04325 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.subject.keyword | peripheral blood stem cell harvest | - |
dc.subject.keyword | hematologic malignancies | - |
dc.subject.keyword | non-hematologic malignancies | - |
dc.subject.keyword | plerixafor | - |
dc.subject.keyword | poor mobilization | - |
dc.contributor.alternativeName | Kim, Sin Young | - |
dc.contributor.affiliatedAuthor | 김신영 | - |
dc.contributor.affiliatedAuthor | 김진석 | - |
dc.contributor.affiliatedAuthor | 안원기 | - |
dc.contributor.affiliatedAuthor | 유철주 | - |
dc.contributor.affiliatedAuthor | 이경아 | - |
dc.contributor.affiliatedAuthor | 정준원 | - |
dc.contributor.affiliatedAuthor | 정해림 | - |
dc.contributor.affiliatedAuthor | 한승민 | - |
dc.contributor.affiliatedAuthor | 한정우 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1821 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.16(10) : 1821, 2024-05 | - |
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