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Alterations in Plasma Cytokine Levels in Korean Children with Autism Spectrum Disorder

Authors
 Songjoo Shim  ;  Sungji Ha  ;  Juli Choi  ;  Ho-Keun Kwon  ;  Keun-Ah Cheon 
Citation
 YONSEI MEDICAL JOURNAL, Vol.65(2) : 70-77, 2024-02 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2024-02
MeSH
Autism Spectrum Disorder* ; Child ; Cytokines* ; Female ; Humans ; Inflammation ; Interferons ; Male ; Tumor Necrosis Factor-alpha
Keywords
Autism spectrum disorder ; Korean ; blood cytokine ; immune dysfunction
Abstract
Purpose: Numerous studies have supported the role of the immune dysfunction in the pathogenesis of autism spectrum disorder (ASD); however, to our knowledge, no study has been conducted on plasma cytokine levels in children with ASD in South Korea. In this study, we aimed to analyze the immunological characteristics of Korean children with ASD through plasma cytokine analysis. Materials and Methods: Blood samples were collected from 94 ASD children (mean age 7.1; 81 males and 13 females) and 48 typically developing children (TDC) (mean age 7.3; 30 males and 18 females). Plasma was isolated from 1 mL of blood by clarifying with centrifugation at 8000 rpm at 4 degrees C for 10 min. Cytokines in plasma were measured with LEGENDplex HU Th cytokine panel (BioLegend, 741028) and LEGENDplex HU cytokine panel 2 (BioLegend, 740102). Results: Among 25 cytokines, innate immune cytokine [interleukin (IL)-33] was significantly decreased in ASD children compared with TDC. In acute phase proteins, tumor necrosis factor alpha (TNF-alpha) was significantly increased, while IL-6, another inflammation marker, was decreased in ASD children compared with TDC. The cytokines from T cell subsets, including interferon (IFN)-gamma, IL-5, IL-13, and IL-17f, were significantly decreased in ASD children compared to TDC. IL-10, a major anti-inflammatory cytokine, and IL-9, which modulates immune cell growth and proliferation, were also significantly decreased in ASD children compared to TDC. Conclusion: We confirmed that Korean children with ASD showed altered immune function and unique cytokine expression patterns distinct from TDC.
Files in This Item:
T202402705.pdf Download
DOI
10.3349/ymj.2023.0362
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ho-Keun(권호근) ORCID logo https://orcid.org/0000-0003-3175-0376
Shim, Songjoo(심송주)
Cheon, Keun Ah(천근아) ORCID logo https://orcid.org/0000-0001-7113-9286
Choi, Juli(최주리)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199202
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