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Alterations in Plasma Cytokine Levels in Korean Children with Autism Spectrum Disorder
DC Field | Value | Language |
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dc.contributor.author | 권호근 | - |
dc.contributor.author | 천근아 | - |
dc.contributor.author | 심송주 | - |
dc.contributor.author | 최주리 | - |
dc.date.accessioned | 2024-05-23T03:19:38Z | - |
dc.date.available | 2024-05-23T03:19:38Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199202 | - |
dc.description.abstract | Purpose: Numerous studies have supported the role of the immune dysfunction in the pathogenesis of autism spectrum disorder (ASD); however, to our knowledge, no study has been conducted on plasma cytokine levels in children with ASD in South Korea. In this study, we aimed to analyze the immunological characteristics of Korean children with ASD through plasma cytokine analysis. Materials and Methods: Blood samples were collected from 94 ASD children (mean age 7.1; 81 males and 13 females) and 48 typically developing children (TDC) (mean age 7.3; 30 males and 18 females). Plasma was isolated from 1 mL of blood by clarifying with centrifugation at 8000 rpm at 4 degrees C for 10 min. Cytokines in plasma were measured with LEGENDplex HU Th cytokine panel (BioLegend, 741028) and LEGENDplex HU cytokine panel 2 (BioLegend, 740102). Results: Among 25 cytokines, innate immune cytokine [interleukin (IL)-33] was significantly decreased in ASD children compared with TDC. In acute phase proteins, tumor necrosis factor alpha (TNF-alpha) was significantly increased, while IL-6, another inflammation marker, was decreased in ASD children compared with TDC. The cytokines from T cell subsets, including interferon (IFN)-gamma, IL-5, IL-13, and IL-17f, were significantly decreased in ASD children compared to TDC. IL-10, a major anti-inflammatory cytokine, and IL-9, which modulates immune cell growth and proliferation, were also significantly decreased in ASD children compared to TDC. Conclusion: We confirmed that Korean children with ASD showed altered immune function and unique cytokine expression patterns distinct from TDC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Autism Spectrum Disorder* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Cytokines* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation | - |
dc.subject.MESH | Interferons | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha | - |
dc.title | Alterations in Plasma Cytokine Levels in Korean Children with Autism Spectrum Disorder | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Songjoo Shim | - |
dc.contributor.googleauthor | Sungji Ha | - |
dc.contributor.googleauthor | Juli Choi | - |
dc.contributor.googleauthor | Ho-Keun Kwon | - |
dc.contributor.googleauthor | Keun-Ah Cheon | - |
dc.identifier.doi | 10.3349/ymj.2023.0362 | - |
dc.contributor.localId | A05782 | - |
dc.contributor.localId | A04027 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 38288647 | - |
dc.subject.keyword | Autism spectrum disorder | - |
dc.subject.keyword | Korean | - |
dc.subject.keyword | blood cytokine | - |
dc.subject.keyword | immune dysfunction | - |
dc.contributor.alternativeName | Kwon, Ho-Keun | - |
dc.contributor.affiliatedAuthor | 권호근 | - |
dc.contributor.affiliatedAuthor | 천근아 | - |
dc.citation.volume | 65 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 70 | - |
dc.citation.endPage | 77 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.65(2) : 70-77, 2024-02 | - |
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