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Effectiveness of the triglyceride-glucose index and triglyceride-glucose-related indices in predicting cardiovascular disease in middle-aged and older adults: A prospective cohort study

Authors
 Hye-Min Park  ;  Taehwa Han  ;  Seok-Jae Heo  ;  Yu-Jin Kwon 
Citation
 JOURNAL OF CLINICAL LIPIDOLOGY, Vol.18(1) : e70-e79, 2024-01 
Journal Title
JOURNAL OF CLINICAL LIPIDOLOGY
ISSN
 1933-2874 
Issue Date
2024-01
MeSH
Aged ; Blood Glucose ; Cardiovascular Diseases* / epidemiology ; Diabetes Mellitus* ; Glucose ; Humans ; Middle Aged ; Prospective Studies ; Risk Factors ; Triglycerides
Keywords
Cardiovascular disease ; Glucose ; Triglyceride ; Waist circumference ; Waist to height ratio
Abstract
Backgrounds: Cardiovascular disease (CVD) risk assessment is a crucial component of public health. We aimed to determine the predictive value of the triglyceride-glucose (TyG) index and TyG-related indices for new-onset CVD.

Methods: This prospective study included 7,808 participants aged 40-69 years from the Ansung-Ansan cohort database. Our analysis was stratified by diabetes status. The hazard ratio (HR) with a 95% confidence interval (CI) for incident CVD was computed using multiple Cox proportional-hazards regression models. To evaluate the predictive performance of these indices for new-onset CVD, we calculated the Harrell's C-index (95% CI).

Results: In this study, a total of 6,890 participants did not have diabetes at baseline, while 918 participants had diabetes. In participants without diabetes, compared to the lowest tertile, fully adjusted HR and 95% CI for new-onset CVD in the highest tertile were as follows: TyG (HR 1.42, 95% CI 1.06-1.90), TyG-body mass index (BMI) (HR 1.92, 95% CI 1.19-3.10), TyG-waist circumference (WC) (HR 2.37, 95% CI 1.61-3.49), and TyG-waist-to-height ratio (WHtR) (HR 2.20, 95% CI 1.47-3.28). However, no significant associations were observed between TyG, modified TyG indices, and new-onset CVD in participants with diabetes. Notably, the C-indice of TyG-WC and TyG-WHtR were significantly higher than those of TyG and TyG-BMI in participants without diabetes.

Conclusions: TyG-BMI, TyG-WC, and TyG-WHtR were associated with an increased risk of new-onset CVD in participants without diabetes. Furthermore, TyG-WC and TyG-WHtR showed better predictive performances for new-onset CVD than TyG and TyG-BMI in participants without diabetes.
Full Text
https://www.sciencedirect.com/science/article/pii/S1933287423003380
DOI
10.1016/j.jacl.2023.11.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
Han, Taehwa(한태화)
Heo, Seok-Jae(허석재) ORCID logo https://orcid.org/0000-0002-8764-7995
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199152
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