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Effectiveness of the triglyceride-glucose index and triglyceride-glucose-related indices in predicting cardiovascular disease in middle-aged and older adults: A prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | 권유진 | - |
dc.contributor.author | 한태화 | - |
dc.contributor.author | 허석재 | - |
dc.date.accessioned | 2024-05-23T03:05:06Z | - |
dc.date.available | 2024-05-23T03:05:06Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 1933-2874 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199152 | - |
dc.description.abstract | Backgrounds: Cardiovascular disease (CVD) risk assessment is a crucial component of public health. We aimed to determine the predictive value of the triglyceride-glucose (TyG) index and TyG-related indices for new-onset CVD. Methods: This prospective study included 7,808 participants aged 40-69 years from the Ansung-Ansan cohort database. Our analysis was stratified by diabetes status. The hazard ratio (HR) with a 95% confidence interval (CI) for incident CVD was computed using multiple Cox proportional-hazards regression models. To evaluate the predictive performance of these indices for new-onset CVD, we calculated the Harrell's C-index (95% CI). Results: In this study, a total of 6,890 participants did not have diabetes at baseline, while 918 participants had diabetes. In participants without diabetes, compared to the lowest tertile, fully adjusted HR and 95% CI for new-onset CVD in the highest tertile were as follows: TyG (HR 1.42, 95% CI 1.06-1.90), TyG-body mass index (BMI) (HR 1.92, 95% CI 1.19-3.10), TyG-waist circumference (WC) (HR 2.37, 95% CI 1.61-3.49), and TyG-waist-to-height ratio (WHtR) (HR 2.20, 95% CI 1.47-3.28). However, no significant associations were observed between TyG, modified TyG indices, and new-onset CVD in participants with diabetes. Notably, the C-indice of TyG-WC and TyG-WHtR were significantly higher than those of TyG and TyG-BMI in participants without diabetes. Conclusions: TyG-BMI, TyG-WC, and TyG-WHtR were associated with an increased risk of new-onset CVD in participants without diabetes. Furthermore, TyG-WC and TyG-WHtR showed better predictive performances for new-onset CVD than TyG and TyG-BMI in participants without diabetes. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL LIPIDOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Blood Glucose | - |
dc.subject.MESH | Cardiovascular Diseases* / epidemiology | - |
dc.subject.MESH | Diabetes Mellitus* | - |
dc.subject.MESH | Glucose | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Triglycerides | - |
dc.title | Effectiveness of the triglyceride-glucose index and triglyceride-glucose-related indices in predicting cardiovascular disease in middle-aged and older adults: A prospective cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Hye-Min Park | - |
dc.contributor.googleauthor | Taehwa Han | - |
dc.contributor.googleauthor | Seok-Jae Heo | - |
dc.contributor.googleauthor | Yu-Jin Kwon | - |
dc.identifier.doi | 10.1016/j.jacl.2023.11.006 | - |
dc.contributor.localId | A04882 | - |
dc.relation.journalcode | J01324 | - |
dc.identifier.pmid | 38044202 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1933287423003380 | - |
dc.subject.keyword | Cardiovascular disease | - |
dc.subject.keyword | Glucose | - |
dc.subject.keyword | Triglyceride | - |
dc.subject.keyword | Waist circumference | - |
dc.subject.keyword | Waist to height ratio | - |
dc.contributor.alternativeName | Kwon, Yu-Jin | - |
dc.contributor.affiliatedAuthor | 권유진 | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | e70 | - |
dc.citation.endPage | e79 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL LIPIDOLOGY, Vol.18(1) : e70-e79, 2024-01 | - |
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