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Hippocampal Perfusion Affects Motor and Cognitive Functions in Parkinson Disease: An Early Phase 18F-FP-CIT Positron Emission Tomography Study

Authors
 Min Young Chun  ;  Seok Jong Chung  ;  Su Hong Kim  ;  Chan Wook Park  ;  Seong Ho Jeong  ;  Hye Sun Lee  ;  Phil Hyu Lee  ;  Young H Sohn  ;  Yong Jeong  ;  Yun Joong Kim 
Citation
 ANNALS OF NEUROLOGY, Vol.95(2) : 388-399, 2024-02 
Journal Title
ANNALS OF NEUROLOGY
ISSN
 0364-5134 
Issue Date
2024-02
MeSH
Cognition ; Dementia* / complications ; Dopamine Plasma Membrane Transport Proteins / metabolism ; Hippocampus / diagnostic imaging ; Hippocampus / metabolism ; Humans ; Parkinson Disease* / complications ; Parkinson Disease* / diagnostic imaging ; Perfusion ; Positron-Emission Tomography / methods ; Tomography, Emission-Computed, Single-Photon / methods ; Tropanes
Abstract
Objectives: We investigated whether hippocampal perfusion changes are associated with cognitive decline, motor deficits, and the risk of dementia conversion in patients with Parkinson's disease (PD).

Methods: We recruited patients with newly diagnosed PD and healthy participants who underwent dual-phase 18F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (18F-FP-CIT) positron emission tomography (PET) scans. Patients were classified into three groups according to hippocampal standard uptake value ratios (SUVRs): 1) the PD hippocampal hypoperfusion group (1 standard deviation [SD] below the mean hippocampal SUVR of healthy controls; PD-hippo-hypo), 2) the PD hippocampal hyperperfusion group (1 SD above the mean; PD-hippo-hyper), and 3) the remaining patients (PD-hippo-normal). We compared the baseline cognitive performance, severity of motor deficits, hippocampal volume, striatal dopamine transporter (DAT) availability, and the risk of dementia conversion among the groups.

Results: We included 235 patients (PD-hippo-hypo: n= 21; PD-hippo-normal: n= 157; and PD-hippo-hyper: n= 57) and 48 healthy participants. Patients in the PD-hippo-hypo group were older and had smaller hippocampal volumes than those in the other PD groups. The PD-hippo-hypo group showed less severely decreased DAT availability in the putamen than the other groups despite similar severities of motor deficit. The PD-hippo-hypo group had a higher risk of dementia conversion than the PD-hippo-normal (hazard ratio, 2.59; p = 0.013) and PD-hippo-hyper (hazard ratio, 3.73; p = 0.006) groups, despite similar cognitive performance at initial assessment between groups.

Interpretation: Hippocampal hypoperfusion may indicate a reduced capacity to cope with neurodegenerative processes in terms of the development of motor deficits and cognitive decline in patients with PD.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/ana.26827
DOI
10.1002/ana.26827
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Yun Joong(김윤중) ORCID logo https://orcid.org/0000-0002-2956-1552
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Chun, Min Young(전민영)
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198704
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