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Hippocampal Perfusion Affects Motor and Cognitive Functions in Parkinson Disease: An Early Phase 18F-FP-CIT Positron Emission Tomography Study
DC Field | Value | Language |
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dc.contributor.author | 김윤중 | - |
dc.contributor.author | 손영호 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 전민영 | - |
dc.contributor.author | 정석종 | - |
dc.date.accessioned | 2024-03-22T07:11:53Z | - |
dc.date.available | 2024-03-22T07:11:53Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 0364-5134 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198704 | - |
dc.description.abstract | Objectives: We investigated whether hippocampal perfusion changes are associated with cognitive decline, motor deficits, and the risk of dementia conversion in patients with Parkinson's disease (PD). Methods: We recruited patients with newly diagnosed PD and healthy participants who underwent dual-phase 18F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (18F-FP-CIT) positron emission tomography (PET) scans. Patients were classified into three groups according to hippocampal standard uptake value ratios (SUVRs): 1) the PD hippocampal hypoperfusion group (1 standard deviation [SD] below the mean hippocampal SUVR of healthy controls; PD-hippo-hypo), 2) the PD hippocampal hyperperfusion group (1 SD above the mean; PD-hippo-hyper), and 3) the remaining patients (PD-hippo-normal). We compared the baseline cognitive performance, severity of motor deficits, hippocampal volume, striatal dopamine transporter (DAT) availability, and the risk of dementia conversion among the groups. Results: We included 235 patients (PD-hippo-hypo: n= 21; PD-hippo-normal: n= 157; and PD-hippo-hyper: n= 57) and 48 healthy participants. Patients in the PD-hippo-hypo group were older and had smaller hippocampal volumes than those in the other PD groups. The PD-hippo-hypo group showed less severely decreased DAT availability in the putamen than the other groups despite similar severities of motor deficit. The PD-hippo-hypo group had a higher risk of dementia conversion than the PD-hippo-normal (hazard ratio, 2.59; p = 0.013) and PD-hippo-hyper (hazard ratio, 3.73; p = 0.006) groups, despite similar cognitive performance at initial assessment between groups. Interpretation: Hippocampal hypoperfusion may indicate a reduced capacity to cope with neurodegenerative processes in terms of the development of motor deficits and cognitive decline in patients with PD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | ANNALS OF NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cognition | - |
dc.subject.MESH | Dementia* / complications | - |
dc.subject.MESH | Dopamine Plasma Membrane Transport Proteins / metabolism | - |
dc.subject.MESH | Hippocampus / diagnostic imaging | - |
dc.subject.MESH | Hippocampus / metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Parkinson Disease* / complications | - |
dc.subject.MESH | Parkinson Disease* / diagnostic imaging | - |
dc.subject.MESH | Perfusion | - |
dc.subject.MESH | Positron-Emission Tomography / methods | - |
dc.subject.MESH | Tomography, Emission-Computed, Single-Photon / methods | - |
dc.subject.MESH | Tropanes | - |
dc.title | Hippocampal Perfusion Affects Motor and Cognitive Functions in Parkinson Disease: An Early Phase 18F-FP-CIT Positron Emission Tomography Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Min Young Chun | - |
dc.contributor.googleauthor | Seok Jong Chung | - |
dc.contributor.googleauthor | Su Hong Kim | - |
dc.contributor.googleauthor | Chan Wook Park | - |
dc.contributor.googleauthor | Seong Ho Jeong | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.contributor.googleauthor | Yong Jeong | - |
dc.contributor.googleauthor | Yun Joong Kim | - |
dc.identifier.doi | 10.1002/ana.26827 | - |
dc.contributor.localId | A00796 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A06416 | - |
dc.contributor.localId | A04666 | - |
dc.relation.journalcode | J00166 | - |
dc.identifier.eissn | 1531-8249 | - |
dc.identifier.pmid | 37962393 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/ana.26827 | - |
dc.contributor.alternativeName | Kim, Yun Joong | - |
dc.contributor.affiliatedAuthor | 김윤중 | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.contributor.affiliatedAuthor | 전민영 | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.citation.volume | 95 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 388 | - |
dc.citation.endPage | 399 | - |
dc.identifier.bibliographicCitation | ANNALS OF NEUROLOGY, Vol.95(2) : 388-399, 2024-02 | - |
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