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Follistatin-like 1 is a myokine regulating lipid mobilization during endurance exercise and recovery

 Ji Sun Nam  ;  Su-Jeong Park  ;  Chul Woo Ahn  ;  Eun-Suk Cho  ;  Hee-Joo Kim  ;  YuSik Kim 
 OBESITY, Vol.32(2) : 352-362, 2024-02 
Journal Title
Issue Date
Cyclic GMP / metabolism ; Follistatin* / metabolism ; Follistatin-Related Proteins* / genetics ; Follistatin-Related Proteins* / metabolism ; Glycerol / metabolism ; Humans ; Lipid Mobilization ; Lipolysis / physiology ; Male ; Myokines ; Sterol Esterase / metabolism
Objective: The aim of this study was to investigate the role of the follistatin-like 1 (Fstl1) and disco-interacting protein 2 homolog A (DIP2a) axis in relation to lipid metabolism during and after endurance exercise and to elucidate the mechanisms underlying the metabolic effects of Fstl1 on adipocytes, considering its regulation by exercise and muscle mass and its link to obesity.

Methods: Twenty-nine sedentary males participated in endurance exercise, and blood samples were collected during and after the exercise. Body composition, Fstl1, glycerol, epinephrine, growth hormone, and atrial natriuretic peptide were measured. 3T3-L1 adipocytes, with or without DIP2a knockdown, were treated with Fstl1 to assess glycerol release, cyclic AMP/cyclic GMP production, and hormone sensitive lipase phosphorylation. The association between DIP2a gene expression levels in human adipose tissues and exercise-induced lipolysis was examined.

Results: Fstl1 levels significantly increased during endurance exercise and following recovery, correlating with lean body mass and lipolysis. In 3T3-L1 adipocytes, Fstl1 increased glycerol release, cyclic GMP production, and hormone sensitive lipase activation, but these effects were attenuated by DIP2a knockdown. DIP2a gene expression in human adipose tissues correlated with serum glycerol concentrations during endurance exercise.

Conclusions: Fstl1 is a myokine facilitating lipid mobilization during and after endurance exercise through DIP2a-mediated lipolytic effects in adipocytes.
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1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu-Sik(김유식)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Cho, Eun Suk(조은석)
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