0 84

Cited 1 times in

Breast Tissue Reconstruction Using Polycaprolactone Ball Scaffolds in a Partial Mastectomy Pig Model

Authors
 Kyu-Sik Shim  ;  Da Hye Ryu  ;  Han-Saem Jo  ;  Ki-Bum Kim  ;  Do-Hyun Kim  ;  Yong-Kyu Park  ;  Min Heo  ;  Hee-Eun Cho  ;  Eul-Sik Yoon  ;  Won Jai Lee  ;  Tai Suk Roh  ;  Seung Yong Song  ;  Wooyeol Baek 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.20(4) : 607-619, 2023-07 
Journal Title
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
ISSN
 1738-2696 
Issue Date
2023-07
MeSH
Animals ; Breast Neoplasms* ; Collagen / chemistry ; Female ; Humans ; Mastectomy ; Mastectomy, Segmental ; Quality of Life ; Swine ; Tissue Scaffolds* / chemistry
Keywords
Adipose tissue ; Breast tissue reconstruction ; Collagen ; Partial mastectomy ; Polycaprolactone
Abstract
BACKGROUND: Breast cancer patients suffer from lowered quality of life (QoL) after surgery. Breast conservancy surgery (BCS) such as partial mastectomy is being practiced and studied as an alternative to solve this problem. This study confirmed breast tissue reconstruction in a pig model by fabricating a 3-dimensional (3D) printed Polycaprolactone spherical scaffold (PCL ball) to fit the tissue resected after partial mastectomy.


METHODS: A 3D printed Polycaprolactone spherical scaffold with a structure that can help adipose tissue regeneration was produced using computer-aided design (CAD). A physical property test was conducted for optimization. In order to enhance biocompatibility, collagen coating was applied and a comparative study was conducted for 3 months in a partial mastectomy pig model.


RESULTS: In order to identify adipose tissue and fibroglandular tissue, which mainly constitute breast tissue, the degree of adipose tissue and collagen regeneration was confirmed in a pig model after 3 months. As a result, it was confirmed that a lot of adipose tissue was regenerated in the PCL ball, whereas more collagen was regenerated in the collagen-coated Polycaprolactone spherical scaffold (PCL–COL ball). In addition, as a result of confirming the expression levels of TNF-a and IL-6, it was confirmed that PCL ball showed higher levels than PCL–COL ball.


CONCLUSION: Through this study, we were able to confirm the regeneration of adipose tissue through a 3-dimensional structure in a pig model. Studies were conducted on medium and large-sized animal models for the final purpose of clinical use and reconstruction of human breast tissue, and the possibility was confirmed.
Full Text
https://link.springer.com/article/10.1007/s13770-023-00528-x
DOI
10.1007/s13770-023-00528-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Roh, Tai Suk(노태석) ORCID logo https://orcid.org/0000-0001-8681-159X
Ryu, Da Hye(류다혜)
Baek, Wooyeol(백우열) ORCID logo https://orcid.org/0000-0002-6638-4110
Song, Seung Yong(송승용) ORCID logo https://orcid.org/0000-0002-3145-7463
Lee, Won Jai(이원재) ORCID logo https://orcid.org/0000-0003-3056-0503
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198199
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links