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Harmful effect of repetitive intravenous iodinated contrast media administration on the long-term renal function of patients with early gastric cancer

 Ja Ho Koo  ;  Myeongjee Lee  ;  Eun Hwa Kim  ;  Hyung Jung Oh  ;  Joon Seok Lim  ;  Woo Jin Hyung  ;  Hong In Yoon  ;  Inkyung Jung  ;  Yong Eun Chung 
 SCIENTIFIC REPORTS, Vol.13(1) : 19448, 2023-11 
Journal Title
Issue Date
Case-Control Studies ; Contrast Media ; Humans ; Insurance, Health ; Iodine Compounds* ; Kidney / diagnostic imaging ; Kidney / physiology ; Renal Insufficiency, Chronic* / chemically induced ; Renal Insufficiency, Chronic* / drug therapy ; Retrospective Studies ; Risk Factors ; Stomach Neoplasms* / diagnostic imaging ; Stomach Neoplasms* / drug therapy
This retrospective study investigated whether repetitive exposure to intravenous iodinated contrast media (ICM) affects long-term renal function in patients who undergo curative surgery for early gastric cancer (EGC) collected from the Korean Health Insurance and Review Assessment (HIRA) database. Patients diagnosed with gastric cancer between January 2010 and December 2013 underwent regular computed tomography (CT) scans to monitor for extragastric recurrence. Patients who already had chronic kidney disease (CKD) before cancer diagnosis or had undergone chemotherapy or repeated surgery were excluded. A nested case-control study design was chosen to analyze the effect of repetitive ICM exposure to long-term renal function by comparing patients who developed CKD 2 years after cancer diagnosis and patients who did not. Among 59,971 patients collected according to inclusion and exclusion criteria, 1021 were diagnosed with CKD 2 years after cancer diagnosis. Using 1:5 matching after adjusting for age, sex and date of cancer diagnosis, 5097 control patients were matched to 1021 CKD patients. Conditional logistic regression showed that the number of CTs taken using ICM slightly increased the odds of CKD (odds ratio, 1.080; 95% confidence interval (CI): 1.059, 1.100; P < 0.0001). Thus, the administration of ICM might contribute to chronic renal function impairment.
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1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Ho(구자호)
Yoon, Hong In(윤홍인) ORCID logo https://orcid.org/0000-0002-2106-6856
Lee, Myeongjee(이명지)
Lim, Joon Seok(임준석) ORCID logo https://orcid.org/0000-0002-0334-5042
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
Jung, Inkyung(정인경) ORCID logo https://orcid.org/0000-0003-3780-3213
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
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