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A novel orthodontic adhesive containing zinc-doped phosphate-based glass for preventing white spot lesions

 Min-Ji Kim  ;  Ji-Young Seo  ;  Il-Jun Jung  ;  Utkarsh Mangal  ;  Hee-Jin Kim  ;  Kee-Joon Lee  ;  Myung-Jin Lee  ;  Jae-Sung Kwon  ;  Sung-Hwan Choi 
 JOURNAL OF DENTISTRY, Vol.137 : 104689, 2023-10 
Journal Title
Issue Date
Calcium ; Dental Caries* ; Dental Cements* ; Humans ; Phosphates ; Powders
Orthodontic adhesives ; Remineralization ; White spot lesions ; Zinc-doped phosphate-based glass
Objectives: This study aimed at demonstrating the remineralization effect of the enamel around the brackets to aid reduction in white spot lesions (WSLs) with use of zinc-doped phosphate-based glass (Zn-PBG) containing orthodontic adhesives.

Methods: Zn-PBG powder was synthesized, and particle morphology, size, and density were evaluated. Orthodontic adhesives with increasing loading percentage of Zn-PBG powder were prepared: ZnPG3 (3 wt.%), ZnPG6 (6 wt.%), and ZnPG9 (9 wt.%). Brackets were bonded on the etched enamel surface and stored in distilled water (DW) for 1 h. Following, Shear bond strength (SBS) along with adhesive remnant index were analyzed. The release of calcium (Ca), phosphorus (P), and zinc (Zn) from adhesive specimens in DW was evaluated after 7, 15 and 30 days of immersion. The remineralization effect was confirmed by microhardness and surface morphology analysis with scanning electron microscopy.

Results: The SBS value was observed between 20 and 22 MPa on enamel surface. The concentration of Ca, P and Zn released in DW increased with loading percentage of Zn-PBG. The microhardness increased in the experimental groups after immersion in artificial saliva for 7 days. Apatite-like crystal formation was observed after 30 days in the ZnPG 9 group.

Conclusions: The orthodontic adhesive containing Zn-PBG with an optimal SBS performance has an enamel remineralization effect, and therefore can aid in prevention of WSLs.

Clinical significance: The orthodontic adhesive containing Zn-PBG is clinically advantageous as it can promote remineralization and resist the formation of WSLs that may occur during orthodontic therapy.
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2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Kim, Hee Jin(김희진) ORCID logo https://orcid.org/0000-0002-1139-6261
Mangal, Utkarsh(만갈웃커시)
Lee, Kee Joon(이기준) ORCID logo https://orcid.org/0000-0002-0782-3128
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
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