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Effect of strontium substitution on functional activity of phosphate-based glass

 Jeong-Hyun Ryu  ;  Utkarsh Mangal  ;  Myung-Jin Lee  ;  Ji-Young Seo  ;  Il Jun Jeong  ;  Jin-Young Park  ;  Ji-Yeong Na  ;  Kee-Joon Lee  ;  Hyung-Seog Yu  ;  Jae-Kook Cha  ;  Jae-Sung Kwon  ;  Sung-Hwan Choi 
 BIOMATERIALS SCIENCE, Vol.11(18) : 6299-6310, 2023-09 
Journal Title
Issue Date
Animals ; Bone Regeneration* ; Cell Line ; Glass / chemistry ; Osteogenesis* ; Phosphates ; Rabbits ; Strontium / chemistry ; Strontium / pharmacology
Phosphate-based glass (PBG) is a bioactive agent, composed of a glass network with phosphate as the primary component and can be substituted with various therapeutic ions for functional enhancement. Strontium (Sr) has been shown to stimulate osteogenic activity and inhibit pro-inflammatory responses. Despite this potential, there are limited studies that focus on the proportion of Sr substituted and its impact on the functional activity of resulting Sr-substituted PBG (PSr). In this study, focusing on the cellular biological response we synthesized and investigated the functional activity of PSr by characterizing its properties and comparing the effect of Sr substitution on cellular bioactivity. Moreover, we benchmarked the optimal composition against 45S5 bioactive glass (BG). Our results showed that PSr groups exhibited a glass structure and phosphate network like that of PBG. The release of Sr and P was most stable for PSr6, which showed favorable cell viability. Furthermore, PSr6 elicited excellent early osteogenic marker expression and inhibition of pro-inflammatory cytokine expression, which was significant compared to BG. In addition, compared to BG, PSr6 had markedly higher expression of osteopontin in immunocytochemistry, higher ALP expression in osteogenic media, and denser alizarin red staining in vitro. We also observed a comparable in vivo regenerative response in a 4-week rabbit calvaria defect model. Therefore, based on the results of this study, PSr6 could be identified as the functionally optimized composition with the potential to be applied as a valuable bioactive component of existing biomaterials used for bone regeneration.
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2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Mangal, Utkarsh(만갈웃커시)
Park, Jin Young(박진영)
Yu, Hyung Seog(유형석) ORCID logo https://orcid.org/0000-0002-1275-5078
Lee, Kee Joon(이기준) ORCID logo https://orcid.org/0000-0002-0782-3128
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
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