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Korean Red Ginseng Potentially Improves Maintaining Antibodies after COVID-19 Vaccination: A 24-Week Longitudinal Study

 Jihyun Yoon  ;  Byoungjin Park  ;  Heejung Kim  ;  Seungjun Choi  ;  Donghyuk Jung 
 NUTRIENTS, Vol.15(7) : 1584, 2023-04 
Journal Title
Issue Date
Antibodies OR COVID-19 Vaccines* / immunology OR COVID-19* / prevention & control OR Humans OR Longitudinal Studies OR Middle Aged OR Panax* OR Pilot Projects OR Vaccination
COVID-19 ; Korean Red Ginseng ; humoral immunity ; immunomodulator ; vaccination
Despite the effectiveness and safety of COVID-19 vaccines, vaccine-induced responses decline over time; thus, booster vaccines have been approved globally. In addition, interest in natural compounds capable of improving host immunity has increased. This study aimed to examine the effect of Korean Red Ginseng (KRG) on virus-specific antibodies after COVID-19 vaccination. We conducted a 24 week clinical pilot study of 350 healthy subjects who received two doses of the COVID-19 vaccine and a booster vaccination (third dose). These subjects were randomized 1:2 to the KRG and control groups. We evaluated antibody response five times: just before the second dose (baseline), 2 weeks, 4 weeks, 12 weeks after the second dose, and 4 weeks after the third dose. The primary endpoints were changes in COVID-19 spike antibody titers and neutralizing antibody titers. The antibody formation rate of the KRG group was sustained higher than that of the control group for 12 weeks after the second dose. This trend was prominently observed in those above 50 years old. We found that KRG can help to increase and maintain vaccine response, highlighting that KRG could potentially be used as an immunomodulator with COVID-19 vaccines. © 2023 by the authors.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heejung(김희정) ORCID logo https://orcid.org/0000-0002-0190-703X
Park, Byoungjin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Yoon, Jihyun(윤지현) ORCID logo https://orcid.org/0000-0002-1057-2235
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
Choi, Seung Jun(최승준) ORCID logo https://orcid.org/0000-0003-0736-1055
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