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Dynamic Nuclear Polarization of Selectively 29Si-Enriched Core@shell Silica Nanoparticles

Authors
 Jiwon Kim  ;  Incheol Heo  ;  Quy Son Luu  ;  Quynh Thi Nguyen  ;  Uyen Thi Do  ;  Nicholas Whiting  ;  Seung-Hyun Yang  ;  Yong-Min Huh  ;  Sun-Joon Min  ;  Jeong Hyun Shim  ;  Won Cheol Yoo  ;  Youngbok Lee 
Citation
 ANALYTICAL CHEMISTRY, Vol.95(2) : 907-916, 2023-01 
Journal Title
ANALYTICAL CHEMISTRY
ISSN
 0003-2700 
Issue Date
2023-01
Keywords
Contrast Media / chemistry ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Nanoparticles* / chemistry ; Silicon Dioxide* / chemistry
Abstract
29Si silica nanoparticles (SiO2 NPs) are promising magnetic resonance imaging (MRI) probes that possess advantageous properties for in vivo applications, including suitable biocompatibility, tailorable properties, and high water dispersibility. Dynamic nuclear polarization (DNP) is used to enhance 29Si MR signals via enhanced nuclear spin alignment; to date, there has been limited success employing DNP for SiO2 NPs due to the lack of endogenous electronic defects that are required for the process. To create opportunities for SiO2-based 29Si MRI probes, we synthesized variously featured SiO2 NPs with selective 29Si isotope enrichment on homogeneous and core@shell structures (shell thickness: 10 nm, core size: 40 nm), and identified the critical factors for optimal DNP signal enhancement as well as the effective hyperpolarization depth when using an exogenous radical. Based on the synthetic design, this critical factor is the proportion of 29Si in the shell layer regardless of core enrichment. Furthermore, the effective depth of hyperpolarization is less than 10 nm between the surface and core, which demonstrates an approximately 40% elongated diffusion length for the shell-enriched NPs compared to the natural abundance NPs. This improved regulation of surface properties facilitates the development of isotopically enriched SiO2 NPs as hyperpolarized contrast agents for in vivo MRI.
Full Text
https://pubs.acs.org/doi/abs/10.1021/acs.analchem.2c03464
DOI
10.1021/acs.analchem.2c03464
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Yang, Seung Hyun(양승현) ORCID logo https://orcid.org/0000-0002-0909-7828
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/194221
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