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Non-invasive and depth-free temperature monitoring using MR thermometry in plasmonic photothermal therapy using gold nanorods

Authors
 Seung-Hyun Yang  ;  Kiyoung Jeong  ;  Jaemoon Yang  ;  Hye Young Son  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seung Jae Oh 
Citation
 CURRENT APPLIED PHYSICS, Vol.45 : 12-17, 2023-01 
Journal Title
CURRENT APPLIED PHYSICS
ISSN
 1567-1739 
Issue Date
2023-01
Keywords
Plasmonic photothermal therapy ; Gold nanorods ; MR thermometry ; Tumor phantom ; Heat transfer
Abstract
This study used magnetic resonance (MR) thermometry to investigate the temperature increases and thermal transfer that occur during plasmonic photothermal therapy (PTT) with gold nanorods (GNRs). An artificial tumor phantom made of agarose gel containing GNRs was heated by irradiation with an 808 nm laser. The MR thermometry visualized the conditions: a well-localized temperature distribution with suppressed thermal diffusion that depended on laser power and irradiation time. A tumor phantom model was implanted in mice, and MR thermometry evaluated the temperature change in the presence and absence of GNRs and the thermal transfer into the surrounding tissues. That experiment showed that MR thermometry can be a useful tool for monitoring PTT. These results suggest that MR temperature measurement could help to establish ideal laser irradiation conditions in GNR-mediated PTT, and that it has great potential for visualizing local photothermal induction and evaluating therapeutic effects.
Full Text
https://www.sciencedirect.com/science/article/pii/S1567173922002450
DOI
10.1016/j.cap.2022.10.004
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Son, Hye Yeong(손혜영) ORCID logo https://orcid.org/0000-0001-5977-6784
Yang, Seung Hyun(양승현) ORCID logo https://orcid.org/0000-0002-0909-7828
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Oh, Seung Jae(오승재)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/194213
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