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Comparing the efficacy of different methods of faecal microbiota transplantation via oral capsule, oesophagogastroduodenoscopy, colonoscopy, or gastric tube

Authors
 E H Lee  ;  S K Lee  ;  J H Cheon  ;  H Koh  ;  J A Lee  ;  C H Kim  ;  J N Kim  ;  K H Lee  ;  S J Lee  ;  J H Kim  ;  J Y Ahn  ;  S J Jeong  ;  N S Ku  ;  D E Yong  ;  S S Yoon  ;  J S Yeom  ;  J Y Choi 
Citation
 JOURNAL OF HOSPITAL INFECTION, Vol.131 : 234-243, 2023-01 
Journal Title
JOURNAL OF HOSPITAL INFECTION
ISSN
 0195-6701 
Issue Date
2023-01
MeSH
Anti-Bacterial Agents* / pharmacology ; Anti-Bacterial Agents* / therapeutic use ; Colonoscopy ; Endoscopy, Digestive System ; Fecal Microbiota Transplantation* / methods ; Feces ; Humans ; Prospective Studies ; Treatment Outcome
Keywords
Decolonization ; Faecal microbiota transplantation ; Multidrug-resistant organism
Abstract
Background: The increasing prevalence of multidrug-resistant organism (MDRO) carriage poses major challenges to medicine as healthcare costs increase. Recently, faecal microbiota transplantation (FMT) has been discussed as a novel and effective method for decolonizing MDRO.

Aim: To compare the efficacy of different FMT methods to optimize the success rate of decolonization in patients with MDRO carriage.

Methods: This prospective cohort study enrolled patients with MDRO carriages from 2018 to 2021. Patients underwent FMT via one of the following methods: oral capsule, oesophagogastroduodenoscopy (EGD), colonoscopy, or gastric tube.

Findings: A total of 57 patients underwent FMT for MDRO decolonization. The colonoscopy group required the shortest time for decolonization, whereas the EGD group required the longest (24.9 vs 190.4 days, P = 0.022). The decolonization rate in the oral capsule group was comparable to that in the EGD group (84.6% vs 85.7%, P = 0.730). An important clinical factor associated with decolonization failure was antibiotic use after FMT (odds ratio = 6.810, P = 0.008). All four groups showed reduced proportions of MDRO species in microbiome analysis after FMT.

Conclusion: Compared to other conventional methods, the oral capsule is an effective FMT method for patients who can tolerate an oral diet. The discontinuation of antibiotics after FMT is a key factor in the success of decolonization.
Full Text
https://www.sciencedirect.com/science/article/pii/S0195670122003590
DOI
10.1016/j.jhin.2022.11.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hong(고홍) ORCID logo https://orcid.org/0000-0002-3660-7483
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Jung Ho(김정호) ORCID logo https://orcid.org/0000-0002-5033-3482
Ahn, Jin Young(안진영) ORCID logo https://orcid.org/0000-0002-3740-2826
Yeom, Joon Sup(염준섭) ORCID logo https://orcid.org/0000-0001-8940-7170
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
Lee, Ki Hyun(이기현)
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Se Ju(이세주)
Lee, Eun Hwa(이은화)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193727
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