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Comparing the efficacy of different methods of faecal microbiota transplantation via oral capsule, oesophagogastroduodenoscopy, colonoscopy, or gastric tube

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dc.contributor.author고홍-
dc.contributor.author구남수-
dc.contributor.author김정호-
dc.contributor.author안진영-
dc.contributor.author염준섭-
dc.contributor.author용동은-
dc.contributor.author윤상선-
dc.contributor.author이상길-
dc.contributor.author정수진-
dc.contributor.author천재희-
dc.contributor.author최준용-
dc.contributor.author이은화-
dc.contributor.author이상길-
dc.contributor.author이기현-
dc.contributor.author이세주-
dc.date.accessioned2023-03-27T02:50:58Z-
dc.date.available2023-03-27T02:50:58Z-
dc.date.issued2023-01-
dc.identifier.issn0195-6701-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193727-
dc.description.abstractBackground: The increasing prevalence of multidrug-resistant organism (MDRO) carriage poses major challenges to medicine as healthcare costs increase. Recently, faecal microbiota transplantation (FMT) has been discussed as a novel and effective method for decolonizing MDRO. Aim: To compare the efficacy of different FMT methods to optimize the success rate of decolonization in patients with MDRO carriage. Methods: This prospective cohort study enrolled patients with MDRO carriages from 2018 to 2021. Patients underwent FMT via one of the following methods: oral capsule, oesophagogastroduodenoscopy (EGD), colonoscopy, or gastric tube. Findings: A total of 57 patients underwent FMT for MDRO decolonization. The colonoscopy group required the shortest time for decolonization, whereas the EGD group required the longest (24.9 vs 190.4 days, P = 0.022). The decolonization rate in the oral capsule group was comparable to that in the EGD group (84.6% vs 85.7%, P = 0.730). An important clinical factor associated with decolonization failure was antibiotic use after FMT (odds ratio = 6.810, P = 0.008). All four groups showed reduced proportions of MDRO species in microbiome analysis after FMT. Conclusion: Compared to other conventional methods, the oral capsule is an effective FMT method for patients who can tolerate an oral diet. The discontinuation of antibiotics after FMT is a key factor in the success of decolonization.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherW.B. Saunders For The Hospital Infection Society-
dc.relation.isPartOfJOURNAL OF HOSPITAL INFECTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnti-Bacterial Agents* / pharmacology-
dc.subject.MESHAnti-Bacterial Agents* / therapeutic use-
dc.subject.MESHColonoscopy-
dc.subject.MESHEndoscopy, Digestive System-
dc.subject.MESHFecal Microbiota Transplantation* / methods-
dc.subject.MESHFeces-
dc.subject.MESHHumans-
dc.subject.MESHProspective Studies-
dc.subject.MESHTreatment Outcome-
dc.titleComparing the efficacy of different methods of faecal microbiota transplantation via oral capsule, oesophagogastroduodenoscopy, colonoscopy, or gastric tube-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학교실)-
dc.contributor.googleauthorE H Lee-
dc.contributor.googleauthorS K Lee-
dc.contributor.googleauthorJ H Cheon-
dc.contributor.googleauthorH Koh-
dc.contributor.googleauthorJ A Lee-
dc.contributor.googleauthorC H Kim-
dc.contributor.googleauthorJ N Kim-
dc.contributor.googleauthorK H Lee-
dc.contributor.googleauthorS J Lee-
dc.contributor.googleauthorJ H Kim-
dc.contributor.googleauthorJ Y Ahn-
dc.contributor.googleauthorS J Jeong-
dc.contributor.googleauthorN S Ku-
dc.contributor.googleauthorD E Yong-
dc.contributor.googleauthorS S Yoon-
dc.contributor.googleauthorJ S Yeom-
dc.contributor.googleauthorJ Y Choi-
dc.identifier.doi10.1016/j.jhin.2022.11.007-
dc.contributor.localIdA00156-
dc.contributor.localIdA00189-
dc.contributor.localIdA00902-
dc.contributor.localIdA02267-
dc.contributor.localIdA02353-
dc.contributor.localIdA02423-
dc.contributor.localIdA02558-
dc.contributor.localIdA02812-
dc.contributor.localIdA03638-
dc.contributor.localIdA04030-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ01445-
dc.identifier.eissn1532-2939-
dc.identifier.pmid36414164-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0195670122003590-
dc.subject.keywordDecolonization-
dc.subject.keywordFaecal microbiota transplantation-
dc.subject.keywordMultidrug-resistant organism-
dc.contributor.alternativeNameKoh, Hong-
dc.contributor.affiliatedAuthor고홍-
dc.contributor.affiliatedAuthor구남수-
dc.contributor.affiliatedAuthor김정호-
dc.contributor.affiliatedAuthor안진영-
dc.contributor.affiliatedAuthor염준섭-
dc.contributor.affiliatedAuthor용동은-
dc.contributor.affiliatedAuthor윤상선-
dc.contributor.affiliatedAuthor이상길-
dc.contributor.affiliatedAuthor정수진-
dc.contributor.affiliatedAuthor천재희-
dc.contributor.affiliatedAuthor최준용-
dc.citation.volume131-
dc.citation.startPage234-
dc.citation.endPage243-
dc.identifier.bibliographicCitationJOURNAL OF HOSPITAL INFECTION, Vol.131 : 234-243, 2023-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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