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Comparing the efficacy of different methods of faecal microbiota transplantation via oral capsule, oesophagogastroduodenoscopy, colonoscopy, or gastric tube
DC Field | Value | Language |
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dc.contributor.author | 고홍 | - |
dc.contributor.author | 구남수 | - |
dc.contributor.author | 김정호 | - |
dc.contributor.author | 안진영 | - |
dc.contributor.author | 염준섭 | - |
dc.contributor.author | 용동은 | - |
dc.contributor.author | 윤상선 | - |
dc.contributor.author | 이상길 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 천재희 | - |
dc.contributor.author | 최준용 | - |
dc.contributor.author | 이은화 | - |
dc.contributor.author | 이상길 | - |
dc.contributor.author | 이기현 | - |
dc.contributor.author | 이세주 | - |
dc.date.accessioned | 2023-03-27T02:50:58Z | - |
dc.date.available | 2023-03-27T02:50:58Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 0195-6701 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193727 | - |
dc.description.abstract | Background: The increasing prevalence of multidrug-resistant organism (MDRO) carriage poses major challenges to medicine as healthcare costs increase. Recently, faecal microbiota transplantation (FMT) has been discussed as a novel and effective method for decolonizing MDRO. Aim: To compare the efficacy of different FMT methods to optimize the success rate of decolonization in patients with MDRO carriage. Methods: This prospective cohort study enrolled patients with MDRO carriages from 2018 to 2021. Patients underwent FMT via one of the following methods: oral capsule, oesophagogastroduodenoscopy (EGD), colonoscopy, or gastric tube. Findings: A total of 57 patients underwent FMT for MDRO decolonization. The colonoscopy group required the shortest time for decolonization, whereas the EGD group required the longest (24.9 vs 190.4 days, P = 0.022). The decolonization rate in the oral capsule group was comparable to that in the EGD group (84.6% vs 85.7%, P = 0.730). An important clinical factor associated with decolonization failure was antibiotic use after FMT (odds ratio = 6.810, P = 0.008). All four groups showed reduced proportions of MDRO species in microbiome analysis after FMT. Conclusion: Compared to other conventional methods, the oral capsule is an effective FMT method for patients who can tolerate an oral diet. The discontinuation of antibiotics after FMT is a key factor in the success of decolonization. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | W.B. Saunders For The Hospital Infection Society | - |
dc.relation.isPartOf | JOURNAL OF HOSPITAL INFECTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anti-Bacterial Agents* / pharmacology | - |
dc.subject.MESH | Anti-Bacterial Agents* / therapeutic use | - |
dc.subject.MESH | Colonoscopy | - |
dc.subject.MESH | Endoscopy, Digestive System | - |
dc.subject.MESH | Fecal Microbiota Transplantation* / methods | - |
dc.subject.MESH | Feces | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Comparing the efficacy of different methods of faecal microbiota transplantation via oral capsule, oesophagogastroduodenoscopy, colonoscopy, or gastric tube | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | E H Lee | - |
dc.contributor.googleauthor | S K Lee | - |
dc.contributor.googleauthor | J H Cheon | - |
dc.contributor.googleauthor | H Koh | - |
dc.contributor.googleauthor | J A Lee | - |
dc.contributor.googleauthor | C H Kim | - |
dc.contributor.googleauthor | J N Kim | - |
dc.contributor.googleauthor | K H Lee | - |
dc.contributor.googleauthor | S J Lee | - |
dc.contributor.googleauthor | J H Kim | - |
dc.contributor.googleauthor | J Y Ahn | - |
dc.contributor.googleauthor | S J Jeong | - |
dc.contributor.googleauthor | N S Ku | - |
dc.contributor.googleauthor | D E Yong | - |
dc.contributor.googleauthor | S S Yoon | - |
dc.contributor.googleauthor | J S Yeom | - |
dc.contributor.googleauthor | J Y Choi | - |
dc.identifier.doi | 10.1016/j.jhin.2022.11.007 | - |
dc.contributor.localId | A00156 | - |
dc.contributor.localId | A00189 | - |
dc.contributor.localId | A00902 | - |
dc.contributor.localId | A02267 | - |
dc.contributor.localId | A02353 | - |
dc.contributor.localId | A02423 | - |
dc.contributor.localId | A02558 | - |
dc.contributor.localId | A02812 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A04030 | - |
dc.contributor.localId | A04191 | - |
dc.relation.journalcode | J01445 | - |
dc.identifier.eissn | 1532-2939 | - |
dc.identifier.pmid | 36414164 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0195670122003590 | - |
dc.subject.keyword | Decolonization | - |
dc.subject.keyword | Faecal microbiota transplantation | - |
dc.subject.keyword | Multidrug-resistant organism | - |
dc.contributor.alternativeName | Koh, Hong | - |
dc.contributor.affiliatedAuthor | 고홍 | - |
dc.contributor.affiliatedAuthor | 구남수 | - |
dc.contributor.affiliatedAuthor | 김정호 | - |
dc.contributor.affiliatedAuthor | 안진영 | - |
dc.contributor.affiliatedAuthor | 염준섭 | - |
dc.contributor.affiliatedAuthor | 용동은 | - |
dc.contributor.affiliatedAuthor | 윤상선 | - |
dc.contributor.affiliatedAuthor | 이상길 | - |
dc.contributor.affiliatedAuthor | 정수진 | - |
dc.contributor.affiliatedAuthor | 천재희 | - |
dc.contributor.affiliatedAuthor | 최준용 | - |
dc.citation.volume | 131 | - |
dc.citation.startPage | 234 | - |
dc.citation.endPage | 243 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HOSPITAL INFECTION, Vol.131 : 234-243, 2023-01 | - |
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