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Effectiveness and safety of injectable human papilloma virus vaccine administered as eyedrops

Authors
 Jiyeon Kim  ;  Eun-Do Kim  ;  Hae-Sol Shin  ;  Soo Jung Han  ;  Munkhdelger Jamiyansharav  ;  Sang Chul Yoon  ;  Jihei Sara Lee  ;  Kyoung Yul Seo 
Citation
 VACCINE, Vol.41(1) : 92-100, 2023-01 
Journal Title
VACCINE
ISSN
 0264-410X 
Issue Date
2023-01
MeSH
Administration, Intranasal ; Animals ; Antibodies, Viral ; Human Papillomavirus Viruses* ; Humans ; Immunity, Mucosal ; Immunoglobulin G ; Influenza Vaccines* ; Mice ; Mice, Inbred BALB C ; Ophthalmic Solutions ; Vaccination ; Substances
Keywords
Cervarix ; Eyedrop vaccine ; HPV vaccine ; Mucosal vaccines
Abstract
Mucosal vaccines have the advantages of ease of administration and the induction of strong mucosal immunity and a systemic immune response. Recently, the eye mucosa has been shown to be an effective and safe alternative vaccination route against influenza, Toxoplasma gondii infection, and hemolytic uremic syndrome in mice. In this study, we showed that the commercially available human papilloma virus (HPV) vaccine, Cervarix, induced significant immune reactions in terms of anti-HPV antigen (Ag)-specific immunoglobulin G (IgG) and IgA antibody production following eyedrop (ED) vaccination in mice. The HPV ED vaccines (EDV) provoked no signs of inflammation within 24 h, as indicated by the inflammatory cytokine mRNA levels and infiltration of mononuclear cells in inoculation sites. Moreover, the morphology of the cornea and retina and intraocular pressure of mice did not change after the HPV EDV. The functions of photoreceptor cells, including rod and cone cells, were normal following the HPV EDV inoculation in mice. These results suggest that Cervarix EDV could be a potent, safe, and effective mucosal vaccine against HPV-associated cancers.
Full Text
https://www.sciencedirect.com/science/article/pii/S0264410X22011926
DOI
10.1016/j.vaccine.2022.09.070
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Seo, Kyoung Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Yoon, Sang Chul(윤상철) ORCID logo https://orcid.org/0000-0003-0454-9597
Lee, Jihei Sara(이지혜)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193567
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