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Effectiveness and safety of injectable human papilloma virus vaccine administered as eyedrops

DC Field Value Language
dc.contributor.author서경률-
dc.contributor.author윤상철-
dc.contributor.author이지혜-
dc.date.accessioned2023-03-22T02:19:12Z-
dc.date.available2023-03-22T02:19:12Z-
dc.date.issued2023-01-
dc.identifier.issn0264-410X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193567-
dc.description.abstractMucosal vaccines have the advantages of ease of administration and the induction of strong mucosal immunity and a systemic immune response. Recently, the eye mucosa has been shown to be an effective and safe alternative vaccination route against influenza, Toxoplasma gondii infection, and hemolytic uremic syndrome in mice. In this study, we showed that the commercially available human papilloma virus (HPV) vaccine, Cervarix, induced significant immune reactions in terms of anti-HPV antigen (Ag)-specific immunoglobulin G (IgG) and IgA antibody production following eyedrop (ED) vaccination in mice. The HPV ED vaccines (EDV) provoked no signs of inflammation within 24 h, as indicated by the inflammatory cytokine mRNA levels and infiltration of mononuclear cells in inoculation sites. Moreover, the morphology of the cornea and retina and intraocular pressure of mice did not change after the HPV EDV. The functions of photoreceptor cells, including rod and cone cells, were normal following the HPV EDV inoculation in mice. These results suggest that Cervarix EDV could be a potent, safe, and effective mucosal vaccine against HPV-associated cancers.-
dc.description.statementOfResponsibilityrestriction-
dc.languageVACCINE-
dc.publisherVACCINE-
dc.relation.isPartOfVACCINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdministration, Intranasal-
dc.subject.MESHAnimals-
dc.subject.MESHAntibodies, Viral-
dc.subject.MESHHuman Papillomavirus Viruses*-
dc.subject.MESHHumans-
dc.subject.MESHImmunity, Mucosal-
dc.subject.MESHImmunoglobulin G-
dc.subject.MESHInfluenza Vaccines*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHOphthalmic Solutions-
dc.subject.MESHVaccination-
dc.subject.MESHSubstances-
dc.titleEffectiveness and safety of injectable human papilloma virus vaccine administered as eyedrops-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorJiyeon Kim-
dc.contributor.googleauthorEun-Do Kim-
dc.contributor.googleauthorHae-Sol Shin-
dc.contributor.googleauthorSoo Jung Han-
dc.contributor.googleauthorMunkhdelger Jamiyansharav-
dc.contributor.googleauthorSang Chul Yoon-
dc.contributor.googleauthorJihei Sara Lee-
dc.contributor.googleauthorKyoung Yul Seo-
dc.identifier.doi10.1016/j.vaccine.2022.09.070-
dc.contributor.localIdA01870-
dc.relation.journalcodeJ02776-
dc.identifier.eissn1358-8745-
dc.identifier.pmid36402660-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0264410X22011926-
dc.subject.keywordCervarix-
dc.subject.keywordEyedrop vaccine-
dc.subject.keywordHPV vaccine-
dc.subject.keywordMucosal vaccines-
dc.contributor.alternativeNameSeo, Kyoung Yul-
dc.contributor.affiliatedAuthor서경률-
dc.citation.volume41-
dc.citation.number1-
dc.citation.startPage92-
dc.citation.endPage100-
dc.identifier.bibliographicCitationVACCINE, Vol.41(1) : 92-100, 2023-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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