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Risk of Dental Discoloration and Enamel Dysplasia in Children Exposed to Tetracycline and Its Derivatives

 Seo Jung Kim  ;  Eun Hwa Kim  ;  Myeongjee Lee  ;  Jee Yeon Baek  ;  Ji Young Lee  ;  Jae Hee Shin  ;  Sung Min Lim  ;  Min Young Kim  ;  Inkyung Jung  ;  Jong Gyun Ahn  ;  Chung-Min Kang  ;  Ji-Man Kang 
 YONSEI MEDICAL JOURNAL, Vol.63(12) : 1113-1120, 2022-12 
Journal Title
Issue Date
Anti-Bacterial Agents* ; Asian People ; Child ; Databases, Factual ; Dental Enamel ; Humans ; Tetracycline*
Korea ; Tooth abnormalities ; dental care for children ; tetracyclines ; tooth discoloration
Purpose: To examine the risk of dental abnormalities after exposure to tetracycline and its derivatives (TCs) in Korean children.

Materials and methods: Children aged 0-17 years with a claim for prescriptions of TCs between 2002 and 2015 were identified from the Sample Research Database 2.0 of the National Health Insurance Service. Children not exposed to TCs were selected as the control group by matching sex and age (1:4). Cumulative incidence rate and relative risk of dental abnormalities after TCs exposure were investigated.

Results: The 10-year cumulative incidence rate in the 0-12 years group was 3.1% [95% confidence interval (CI), 2.3-3.9]. The 10-year cumulative incidence rates were 7.0%, 1.9%, and 1.6% in the 0-7, 8-12, and 13-17 years age groups (95% CI: 4.7-9.3, 1.2-2.6, and 1.3-1.9, respectively). There was no significant difference in the risk of dental abnormalities according to TC exposure among the age groups of 0-7 years [adjusted hazard ratio (aHR)=1.0], 8-12 years (aHR=1.1), and 13-17 years (aHR=1.2).

Conclusion: Short-term exposure to TCs does not appear to increase the risk of dental abnormalities in children aged 0-7 and 0-12 years. Restrictions on the use of TCs in children aged 8-12 years, in some countries, may warrant consideration.
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1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chung Min(강정민) ORCID logo https://orcid.org/0000-0001-7813-3741
Kang, Ji-Man(강지만) ORCID logo https://orcid.org/0000-0002-0678-4964
Ahn, Jong Gyun(안종균) ORCID logo https://orcid.org/0000-0001-5748-0015
Lee, Myeongjee(이명지)
Lim, Sungmin(임성민)
Jung, Inkyung(정인경) ORCID logo https://orcid.org/0000-0003-3780-3213
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