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Fatty Liver Is an Independent Risk Factor for Elevated Intraocular Pressure

 Jun-Hyuk Lee  ;  Yu-Jin Kwon  ;  Hye Sun Lee  ;  Jee Hye Han  ;  Boyoung Joung  ;  Sung Jin Kim 
 NUTRIENTS, Vol.14(21) : 4455, 2022-10 
Journal Title
Issue Date
Adult ; Fatty Liver* / epidemiology ; Glaucoma* / epidemiology ; Glaucoma* / etiology ; Humans ; Insulin Resistance* ; Intraocular Pressure ; Non-alcoholic Fatty Liver Disease* ; Risk Factors
alcoholic liver disease ; fatty liver ; insulin resistance ; intraocular pressure
Elevated intraocular pressure (EIOP) is a major risk factor for glaucoma. Both EIOP and fatty liver share metabolic risk factors, which implies a possible link between EIOP and fatty liver. We aimed to determine the association of fatty liver with EIOP and estimate the effect of fatty liver on EIOP directly and indirectly through insulin resistance. Data from 16,240 adults who underwent health examinations at a single center were analyzed. Multiple logistic regression analyses revealed that fully adjusted odds ratio (OR) and 95% confidence interval (CI) for EIOP in the fatty liver group compared to the non-fatty liver group were 1.36 and 1.08-1.71. Alcoholic liver disease was associated with EIOP in subgroup analysis (OR = 1.80, 95% CI: 1.27-2.56). There was a linear dose-response relationship between EIOP and the severity of fatty liver. Mediation analysis revealed that the total effect of fatty liver on intraocular pressure was 0.90 (0.81-0.99), with a direct effect of 0.81 (0.71-0.90) and an indirect effect of 0.09 (0.06-0.11) through insulin resistance. Fatty liver is independently associated with EIOP. It primarily has a direct effect on intraocular pressure. This suggests that evaluation of EIOP should be considered in patients with fatty liver.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
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