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Breast Tissue Restoration after the Partial Mastectomy Using Polycaprolactone Scaffold

 Seung-Jun Jwa  ;  Jong-Min Won  ;  Do-Hyun Kim  ;  Ki-Bum Kim  ;  Jung-Bok Lee  ;  Min Heo  ;  Kyu-Sik Shim  ;  Han-Saem Jo  ;  Won-Jai Lee  ;  Tai-Suk Roh  ;  Woo-Yeol Ba다 
 POLYMERS, Vol.14(18) : 3817, 2022-09 
Journal Title
Issue Date
breast restoration ; partial mastectomy ; polycaprolactone ; tissue restoration
As breast conserving surgery increases in the surgical treatment of breast cancer, partial mastectomy is also increasing. Polycaprolactone (PCL) is a polymer that is used as an artifact in various parts of the human body based on the biocompatibility and mechanical properties of PCL. Here, we hypothesized that a PCL scaffold can be utilized for the restoration of breast tissue after a partial mastectomy. To demonstrate the hypothesis, a PCL scaffold was fabricated by 3D printing and three types of spherical PCL scaffold including PCL scaffold, PCL scaffold with collagen, and the PCL scaffold with breast tissue fragment were implanted in the rat breast defect model. After 6 months of implantation, the restoration of breast tissue was observed in the PCL scaffold and the expression of collagen in the PCL scaffold with collagen was seen. The expression of TNF-α was significantly increased in the PCL scaffold, but the expression of IL-6 showed no significant difference in all groups. Through this, it showed the possibility of using it as a method to conveniently repair tissue defects after partial mastectomy of the human body.
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1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Roh, Tai Suk(노태석) ORCID logo https://orcid.org/0000-0001-8681-159X
Baek, Wooyeol(백우열) ORCID logo https://orcid.org/0000-0002-6638-4110
Lee, Won Jai(이원재) ORCID logo https://orcid.org/0000-0003-3056-0503
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