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The Impact of Masticatory Function on Cognitive Impairment in Older Patients: A Population-Based Matched Case-Control Study

 Kyung-A Ko  ;  Jin-Young Park  ;  Jung-Seok Lee  ;  Byoung Seok Ye  ;  Ui-Won Jung  ;  Seong-Ho Choi  ;  Jae-Kook Cha 
 YONSEI MEDICAL JOURNAL, Vol.63(8) : 783-789, 2022-08 
Journal Title
Issue Date
Aged ; Case-Control Studies ; Cognitive Dysfunction* ; Cohort Studies ; Dementia* / epidemiology ; Humans ; Middle Aged ; Tooth Loss*
Masticatory function ; cognitive impairment ; dementia ; oral health ; tooth loss
Purpose: The aim of this study was to investigate the association between the changes in masticatory function and cognitive impairment by analyzing longitudinal data of older Korean patients.

Materials and methods: Patients aged over 60 years with dental records between 2005 to 2010 (baseline; T1) and 2014 to 2020 (follow-up; T2) were selected in a single medical center. Based on the dementia diagnosis after T2, the cohort was classified into two groups, the dementia group (n=122) and the control group (n=366). Changes in masticatory function were calculated using the total functional tooth unit (T-FTU) in both groups. The incidence of tooth extraction (%) and the subsequent rehabilitation during the observation period were also evaluated.

Results: In the dementia group, T-FTU significantly decreased from T1 to T2 (9.81±2.78 to 9.11±3.16, respectively, p=0.008), while no significant change was observed in the control group. During the mean observation period of 9 years, significantly more teeth were extracted and neglected to be prosthetically restored in the dementia group than in the control group. Regression analysis revealed that the number of missing teeth neglected [odds ratio (OR)=1.195, 95% confidence interval (CI)=1.025-1.393, p=0.023] and previous alcohol consumption (OR=4.445, 95% CI=1.831-1.795, p=0.001) were the most significant risk factors of dementia.

Conclusion: There might be a causative relationship between the neglected missing dentition and the onset of dementia.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Kyung-A(고경아)
Park, Jin Young(박진영)
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
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