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SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal

Authors
 Tingsheng Yu  ;  Oscar Cazares  ;  Alison D Tang  ;  Hyun-Yi Kim  ;  Tomas Wald  ;  Adya Verma  ;  Qi Liu  ;  Mary Helen Barcellos-Hoff  ;  Stephen N Floor  ;  Han-Sung Jung  ;  Angela N Brooks  ;  Ophir D Klein 
Citation
 DEVELOPMENTAL CELL, Vol.57(5) : 624-637, 2022-03 
Journal Title
DEVELOPMENTAL CELL
ISSN
 1534-5807 
Issue Date
2022-03
MeSH
Alternative Splicing* / genetics ; Animals ; Epithelium / metabolism ; Homeostasis ; Mice ; RNA Splicing* ; Serine-Arginine Splicing Factors / genetics ; Serine-Arginine Splicing Factors / metabolism
Keywords
alternative splicing ; incisor ; intestine ; mouse ; progenitor ; splicing factor ; tissue homeostasis ; tissue renewal
Abstract
Alternative splicing generates distinct mRNA variants and is essential for development, homeostasis, and renewal. Proteins of the serine/arginine (SR)-rich splicing factor family are major splicing regulators that are broadly required for organ development as well as cell and organism viability. However, how these proteins support adult organ function remains largely unknown. Here, we used the continuously growing mouse incisor as a model to dissect the functions of the prototypical SR family protein SRSF1 during tissue homeostasis and renewal. We identified an SRSF1-governed alternative splicing network that is specifically required for dental proliferation and survival of progenitors but dispensable for the viability of differentiated cells. We also observed a similar progenitor-specific role of SRSF1 in the small intestinal epithelium, indicating a conserved function of SRSF1 across adult epithelial tissues. Thus, our findings define a regulatory mechanism by which SRSF1 specifically controls progenitor-specific alternative splicing events to support adult tissue homeostasis and renewal.
Full Text
https://www.sciencedirect.com/science/article/pii/S1534580722000363?via%3Dihub
DOI
10.1016/j.devcel.2022.01.011
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun-Yi(김현이)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189461
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