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SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal

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dc.contributor.author정한성-
dc.contributor.author김현이-
dc.date.accessioned2022-08-23T00:29:41Z-
dc.date.available2022-08-23T00:29:41Z-
dc.date.issued2022-03-
dc.identifier.issn1534-5807-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189461-
dc.description.abstractAlternative splicing generates distinct mRNA variants and is essential for development, homeostasis, and renewal. Proteins of the serine/arginine (SR)-rich splicing factor family are major splicing regulators that are broadly required for organ development as well as cell and organism viability. However, how these proteins support adult organ function remains largely unknown. Here, we used the continuously growing mouse incisor as a model to dissect the functions of the prototypical SR family protein SRSF1 during tissue homeostasis and renewal. We identified an SRSF1-governed alternative splicing network that is specifically required for dental proliferation and survival of progenitors but dispensable for the viability of differentiated cells. We also observed a similar progenitor-specific role of SRSF1 in the small intestinal epithelium, indicating a conserved function of SRSF1 across adult epithelial tissues. Thus, our findings define a regulatory mechanism by which SRSF1 specifically controls progenitor-specific alternative splicing events to support adult tissue homeostasis and renewal.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherCell Press-
dc.relation.isPartOfDEVELOPMENTAL CELL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAlternative Splicing* / genetics-
dc.subject.MESHAnimals-
dc.subject.MESHEpithelium / metabolism-
dc.subject.MESHHomeostasis-
dc.subject.MESHMice-
dc.subject.MESHRNA Splicing*-
dc.subject.MESHSerine-Arginine Splicing Factors / genetics-
dc.subject.MESHSerine-Arginine Splicing Factors / metabolism-
dc.titleSRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorTingsheng Yu-
dc.contributor.googleauthorOscar Cazares-
dc.contributor.googleauthorAlison D Tang-
dc.contributor.googleauthorHyun-Yi Kim-
dc.contributor.googleauthorTomas Wald-
dc.contributor.googleauthorAdya Verma-
dc.contributor.googleauthorQi Liu-
dc.contributor.googleauthorMary Helen Barcellos-Hoff-
dc.contributor.googleauthorStephen N Floor-
dc.contributor.googleauthorHan-Sung Jung-
dc.contributor.googleauthorAngela N Brooks-
dc.contributor.googleauthorOphir D Klein-
dc.identifier.doi10.1016/j.devcel.2022.01.011-
dc.contributor.localIdA03758-
dc.relation.journalcodeJ00714-
dc.identifier.eissn1878-1551-
dc.identifier.pmid35202586-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1534580722000363?via%3Dihub-
dc.subject.keywordalternative splicing-
dc.subject.keywordincisor-
dc.subject.keywordintestine-
dc.subject.keywordmouse-
dc.subject.keywordprogenitor-
dc.subject.keywordsplicing factor-
dc.subject.keywordtissue homeostasis-
dc.subject.keywordtissue renewal-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.affiliatedAuthor정한성-
dc.citation.volume57-
dc.citation.number5-
dc.citation.startPage624-
dc.citation.endPage637-
dc.identifier.bibliographicCitationDEVELOPMENTAL CELL, Vol.57(5) : 624-637, 2022-03-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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