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Parathyroid venous sampling for the preoperative localisation of parathyroid adenoma in patients with primary hyperparathyroidism

Authors
 Joon Ho  ;  Donggyu Kim  ;  Ji-Eun Lee  ;  Namki Hong  ;  Byung Moon Kim  ;  Dong Joon Kim  ;  Jinkyong Kim  ;  Cho Rok Lee  ;  Sang-Wook Kang  ;  Jong Ju Jeong  ;  Kee-Hyun Nam  ;  Woong Youn Chung  ;  Yumie Rhee 
Citation
 SCIENTIFIC REPORTS, Vol.12(1) : 7058, 2022-04 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2022-04
MeSH
Humans ; Hyperparathyroidism, Primary* / diagnostic imaging ; Hyperparathyroidism, Primary* / pathology ; Hyperparathyroidism, Primary* / surgery ; Parathyroid Glands / diagnostic imaging ; Parathyroid Glands / pathology ; Parathyroid Glands / surgery ; Parathyroid Neoplasms* / complications ; Parathyroid Neoplasms* / diagnostic imaging ; Parathyroid Neoplasms* / surgery ; Radiopharmaceuticals ; Technetium Tc 99m Sestamibi
Abstract
Preoperative localisation studies are essential for parathyroidectomy in patients with primary hyperparathyroidism. If the location of abnormal parathyroid glands cannot be identified through non-invasive studies, parathyroid venous sampling (PVS) may be employed. In this study, we evaluated the utility of preoperative PVS in parathyroid surgery. Patients with primary hyperparathyroidism who underwent preoperative PVS at Severance Hospital between January 2015 and June 2020 were identified. Patients for whom the results of non-invasive imaging studies were inconsistent or negative underwent PVS. The results of PVS were compared with operative findings and pathologic results. For 14 patients, the results of preoperative ultrasonography and 99mTc-sestamibi single-photon emission computed tomography (SPECT) were negative; for 20 patients, either the result of only one test was positive, or the results of the two tests were inconsistent. With respect to the lateralisation of diseased adenoma, the results of PVS and pathological examination were inconsistent only for one patient in either group (total: 2/34 patients). This study showed that PVS could be used effectively for preoperative localisation in patients with primary hyperparathyroidism in whom the location of diseased parathyroid glands cannot be determined through non-invasive image studies.
Files in This Item:
T202202477.pdf Download
DOI
10.1038/s41598-022-11238-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sang Wook(강상욱) ORCID logo https://orcid.org/0000-0001-5355-833X
Kim, Dong Kyu(김동규)
Kim, Dong Joon(김동준) ORCID logo https://orcid.org/0000-0002-7035-087X
Kim, Byung Moon(김병문) ORCID logo https://orcid.org/0000-0001-8593-6841
Kim, Jin Kyong(김진경)
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Ji-Eun(이지은)
Lee, Cho Rok(이초록) ORCID logo https://orcid.org/0000-0001-7848-3709
Chung, Woong Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
Ho, Joon(허준) ORCID logo https://orcid.org/0000-0001-9782-0432
Hong, Nam Ki(홍남기) ORCID logo https://orcid.org/0000-0002-8246-1956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189429
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