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Changes in Thoracic Cavity Volume After Bilateral Lung Transplantation

Authors
 Woo Sik Yu  ;  Chul Hwan Park  ;  Hyo Chae Paik  ;  Jin Gu Lee  ;  Seulgi You  ;  Jaeyong Shin  ;  Junho Jung  ;  Seokjin Haam 
Citation
 FRONTIERS IN MEDICINE, Vol.26 : 881119, 2022-05 
Journal Title
FRONTIERS IN MEDICINE
Issue Date
2022-05
Keywords
chest wall remodeling ; lung transplantation ; obstructive lung disease ; restrictive lung disease ; thoracic cavity volume
Abstract
Purpose: End-stage lung diseases result in anatomical changes of the thoracic cavity. However, very few studies have assessed changes in the thoracic cavity after lung transplantation (LTx). This study aimed to evaluate the relationships between thoracic cavity volume (TCV) changes after LTx and underlying lung disease.

Methods: We reviewed 89 patients who underwent a pre-LTx pulmonary function test (PFT), chest computed tomography (CT) scan, and 1-year follow-up CT after LTx. These patients were classified into two groups according to pre-LTx PFT as follows: obstructive group [forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio < 70%] and restrictive group (FEV1/FVC ratio > 70%). We measured TCV using CT scan before and at 1 year after LTx and compared the TCV change in the two groups.

Results: In the restrictive group, TCV increased after LTx (preop: 2,347.8 ± 709.5 mL, 1-year postop: 3,224.4 ± 919.0 mL, p < 0.001). In contrast, in the obstructive group, it decreased after LTx (preop: 4,662.9 ± 1,296.3 mL, 1-year postop: 3,711.1 ± 891.7 mL, p < 0.001). We observed that restrictive lung disease, taller stature, lower body mass index, and larger donor lung were independently associated with increased TCV after LTx.

Conclusion: The disease-specific chest remodeling caused by restriction and hyperinflation is at least, in part, reversible. After LTx, the chest remodeling appears to occur in the opposite direction to the disease-specific remodeling caused by the underlying lung disease in recipients.
Files in This Item:
T202202410.pdf Download
DOI
10.3389/fmed.2022.881119
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Chul Hwan(박철환) ORCID logo https://orcid.org/0000-0002-0004-9475
Paik, Hyo Chae(백효채) ORCID logo https://orcid.org/0000-0001-9309-8235
Shin, Jae Yong(신재용)
Lee, Jin Gu(이진구)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189412
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