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Changes in Thoracic Cavity Volume After Bilateral Lung Transplantation

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dc.contributor.author박철환-
dc.contributor.author백효채-
dc.contributor.author신재용-
dc.contributor.author이진구-
dc.date.accessioned2022-08-23T00:24:09Z-
dc.date.available2022-08-23T00:24:09Z-
dc.date.issued2022-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189412-
dc.description.abstractPurpose: End-stage lung diseases result in anatomical changes of the thoracic cavity. However, very few studies have assessed changes in the thoracic cavity after lung transplantation (LTx). This study aimed to evaluate the relationships between thoracic cavity volume (TCV) changes after LTx and underlying lung disease. Methods: We reviewed 89 patients who underwent a pre-LTx pulmonary function test (PFT), chest computed tomography (CT) scan, and 1-year follow-up CT after LTx. These patients were classified into two groups according to pre-LTx PFT as follows: obstructive group [forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio < 70%] and restrictive group (FEV1/FVC ratio > 70%). We measured TCV using CT scan before and at 1 year after LTx and compared the TCV change in the two groups. Results: In the restrictive group, TCV increased after LTx (preop: 2,347.8 ± 709.5 mL, 1-year postop: 3,224.4 ± 919.0 mL, p < 0.001). In contrast, in the obstructive group, it decreased after LTx (preop: 4,662.9 ± 1,296.3 mL, 1-year postop: 3,711.1 ± 891.7 mL, p < 0.001). We observed that restrictive lung disease, taller stature, lower body mass index, and larger donor lung were independently associated with increased TCV after LTx. Conclusion: The disease-specific chest remodeling caused by restriction and hyperinflation is at least, in part, reversible. After LTx, the chest remodeling appears to occur in the opposite direction to the disease-specific remodeling caused by the underlying lung disease in recipients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Media S.A.-
dc.relation.isPartOfFRONTIERS IN MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleChanges in Thoracic Cavity Volume After Bilateral Lung Transplantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorWoo Sik Yu-
dc.contributor.googleauthorChul Hwan Park-
dc.contributor.googleauthorHyo Chae Paik-
dc.contributor.googleauthorJin Gu Lee-
dc.contributor.googleauthorSeulgi You-
dc.contributor.googleauthorJaeyong Shin-
dc.contributor.googleauthorJunho Jung-
dc.contributor.googleauthorSeokjin Haam-
dc.identifier.doi10.3389/fmed.2022.881119-
dc.contributor.localIdA01722-
dc.contributor.localIdA01846-
dc.contributor.localIdA02140-
dc.contributor.localIdA03225-
dc.relation.journalcodeJ03762-
dc.identifier.eissn2296-858X-
dc.identifier.pmid35721055-
dc.subject.keywordchest wall remodeling-
dc.subject.keywordlung transplantation-
dc.subject.keywordobstructive lung disease-
dc.subject.keywordrestrictive lung disease-
dc.subject.keywordthoracic cavity volume-
dc.contributor.alternativeNamePark, Chul Hwan-
dc.contributor.affiliatedAuthor박철환-
dc.contributor.affiliatedAuthor백효채-
dc.contributor.affiliatedAuthor신재용-
dc.contributor.affiliatedAuthor이진구-
dc.citation.volume26-
dc.citation.startPage881119-
dc.identifier.bibliographicCitationFRONTIERS IN MEDICINE, Vol.26 : 881119, 2022-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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