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Implication of COPB2 Expression on Cutaneous Squamous Cell Carcinoma Pathogenesis

Authors
 Taiqin Chen  ;  Ki-Yeol Kim  ;  Yeongjoo Oh  ;  Hei Cheul Jeung  ;  Kee Yang Chung  ;  Mi Ryung Roh  ;  Xianglan Zhang 
Citation
 CANCERS, Vol.14(8) : 2038, 2022-04 
Journal Title
CANCERS
Issue Date
2022-04
Keywords
COPB2 ; cSCC ; pathogenesis ; tumor immune microenvironment
Abstract
The underlying molecular mechanisms of cutaneous squamous cell carcinoma (cSCC) pathogenesis are largely unknown. In the present study, we aimed to evaluate the effect of coatomer protein complex subunit beta 2 (COPB2) expression on cSCC pathogenesis. Clinicopathological significance of COPB2 in cSCC was investigated by analyzing the Gene Expression Omnibus (GEO) database and through a retrospective cohort study of 95 cSCC patients. The effect of COPB2 expression on the biological behavior of cSCC cells was investigated both in vitro and in vivo. We found that COPB2 expression was significantly higher in cSCC samples than in normal skin samples. In our cohort, a considerable association was found between COPB2 expression and indicators of tumor immune microenvironment (TIME), such as histocompatibility complex class (MHC) I, and MHC II, CD4+/ CD8+ tumor-infiltrating lymphocytes. Additionally, COPB2 expression had an independent impact on worsened recurrence-free survival in our cohort. Furthermore, decreased proliferation, invasion, tumorigenic activities, and increased apoptosis were observed after COPB2 knockdown in cSCC cells. COPB2 may act as a potential oncogene and candidate modulator of the TIME in cSCC. Therefore, it can serve as a novel predictive prognostic biomarker and candidate immunotherapeutic target in cSCC patients.
Files in This Item:
T202201631.pdf Download
DOI
10.3390/cancers14082038
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kim, Ki Yeol(김기열) ORCID logo https://orcid.org/0000-0001-5357-1067
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Oh, Yeongjoo(오영주) ORCID logo https://orcid.org/0000-0003-4973-9335
Zhang, Xiang Lan(장향란)
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188801
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