Cited 3 times in
Implication of COPB2 Expression on Cutaneous Squamous Cell Carcinoma Pathogenesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김기열 | - |
dc.contributor.author | 노미령 | - |
dc.contributor.author | 오영주 | - |
dc.contributor.author | 장향란 | - |
dc.contributor.author | 정기양 | - |
dc.contributor.author | 정희철 | - |
dc.date.accessioned | 2022-07-08T03:20:54Z | - |
dc.date.available | 2022-07-08T03:20:54Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188801 | - |
dc.description.abstract | The underlying molecular mechanisms of cutaneous squamous cell carcinoma (cSCC) pathogenesis are largely unknown. In the present study, we aimed to evaluate the effect of coatomer protein complex subunit beta 2 (COPB2) expression on cSCC pathogenesis. Clinicopathological significance of COPB2 in cSCC was investigated by analyzing the Gene Expression Omnibus (GEO) database and through a retrospective cohort study of 95 cSCC patients. The effect of COPB2 expression on the biological behavior of cSCC cells was investigated both in vitro and in vivo. We found that COPB2 expression was significantly higher in cSCC samples than in normal skin samples. In our cohort, a considerable association was found between COPB2 expression and indicators of tumor immune microenvironment (TIME), such as histocompatibility complex class (MHC) I, and MHC II, CD4+/ CD8+ tumor-infiltrating lymphocytes. Additionally, COPB2 expression had an independent impact on worsened recurrence-free survival in our cohort. Furthermore, decreased proliferation, invasion, tumorigenic activities, and increased apoptosis were observed after COPB2 knockdown in cSCC cells. COPB2 may act as a potential oncogene and candidate modulator of the TIME in cSCC. Therefore, it can serve as a novel predictive prognostic biomarker and candidate immunotherapeutic target in cSCC patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Implication of COPB2 Expression on Cutaneous Squamous Cell Carcinoma Pathogenesis | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Others | - |
dc.contributor.googleauthor | Taiqin Chen | - |
dc.contributor.googleauthor | Ki-Yeol Kim | - |
dc.contributor.googleauthor | Yeongjoo Oh | - |
dc.contributor.googleauthor | Hei Cheul Jeung | - |
dc.contributor.googleauthor | Kee Yang Chung | - |
dc.contributor.googleauthor | Mi Ryung Roh | - |
dc.contributor.googleauthor | Xianglan Zhang | - |
dc.identifier.doi | 10.3390/cancers14082038 | - |
dc.contributor.localId | A00337 | - |
dc.contributor.localId | A01278 | - |
dc.contributor.localId | A05152 | - |
dc.contributor.localId | A03489 | - |
dc.contributor.localId | A03582 | - |
dc.contributor.localId | A03794 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 35454945 | - |
dc.subject.keyword | COPB2 | - |
dc.subject.keyword | cSCC | - |
dc.subject.keyword | pathogenesis | - |
dc.subject.keyword | tumor immune microenvironment | - |
dc.contributor.alternativeName | Kim, Ki Yeol | - |
dc.contributor.affiliatedAuthor | 김기열 | - |
dc.contributor.affiliatedAuthor | 노미령 | - |
dc.contributor.affiliatedAuthor | 오영주 | - |
dc.contributor.affiliatedAuthor | 장향란 | - |
dc.contributor.affiliatedAuthor | 정기양 | - |
dc.contributor.affiliatedAuthor | 정희철 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2038 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.14(8) : 2038, 2022-04 | - |
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