0 109

Cited 0 times in

Associations between white matter hyperintensities, striatal dopamine loss, and cognition in drug-naïve Parkinson's disease

Authors
 Seong Ho Jeong  ;  Hye Sun Lee  ;  Jin Ho Jung  ;  Kyoungwon Baik  ;  Young H Sohn  ;  Seok Jong Chung  ;  Phil Hyu Lee 
Citation
 PARKINSONISM & RELATED DISORDERS, Vol.97 : 1-7, 2022-04 
Journal Title
PARKINSONISM & RELATED DISORDERS
ISSN
 1353-8020 
Issue Date
2022-04
MeSH
Cognition ; Cognitive Dysfunction* / complications ; Cognitive Dysfunction* / etiology ; Cross-Sectional Studies ; Dopamine ; Dopamine Plasma Membrane Transport Proteins / metabolism ; Humans ; Leukoaraiosis* / pathology ; Magnetic Resonance Imaging / adverse effects ; Parkinson Disease* / complications ; Parkinson Disease* / diagnostic imaging ; Parkinson Disease* / pathology ; White Matter* / pathology
Keywords
Cognition ; Dopamine transporter ; Mediation analysis ; Parkinson's disease ; White matter hyperintensities
Abstract
Introduction: This study investigated the relationship between white matter hyperintensities (WMHs), nigrostriatal dopamine deficits, and cognitive decline in patients with drug-naïve early-stage Parkinson's disease (PD).

Method: This cross-sectional study enrolled 309 non-demented patients with de novo PD who underwent [18F] N-(3-fluoropropyl)-2β-carbonethoxy-3β-(4-iodophenyl) nortropane positron emission tomography, brain magnetic resonance imaging, and a detailed neuropsychological test at baseline. We quantified dopamine transporter (DAT) availability in each striatal sub-region and applied the Scheltens scale to assess the severity of periventricular and deep WMHs. The relationships between WMHs, DAT availability, and cognition in PD were assessed using multivariate linear regression and mediation analyses while adjusting for age at parkinsonian symptom onset, sex, disease duration, and vascular risk factors.

Results: The severities of periventricular and frontal WMHs were associated with striatal DAT availability. Periventricular WMHs affected the level of cognitive performance in all cognitive domains, while frontal WMHs affected the attention/working memory and frontal/executive function domains. The effects of WMHs on attention/working memory and frontal/executive dysfunction were mostly direct with minimal mediating effects through striatal DAT availability. Meanwhile, striatal DAT availability fully mediated the association between WMHs and cognitive impairment in the visuospatial and memory function domains.

Conclusion: This study demonstrated the different effects of WMHs on cognitive impairment depending on the cognitive domains in PD. These findings suggest a close link between comorbid WMHs, striatal dopamine depletion, and cognition in patients with PD.
Full Text
https://www.sciencedirect.com/science/article/pii/S1353802022000530?via%3Dihub
DOI
10.1016/j.parkreldis.2022.02.020
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Baik, Kyoungwon(백경원) ORCID logo https://orcid.org/0000-0001-7215-375X
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188757
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links