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Associations between white matter hyperintensities, striatal dopamine loss, and cognition in drug-naïve Parkinson's disease

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dc.contributor.author손영호-
dc.contributor.author이필휴-
dc.contributor.author이혜선-
dc.contributor.author정석종-
dc.contributor.author백경원-
dc.date.accessioned2022-07-08T03:16:41Z-
dc.date.available2022-07-08T03:16:41Z-
dc.date.issued2022-04-
dc.identifier.issn1353-8020-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188757-
dc.description.abstractIntroduction: This study investigated the relationship between white matter hyperintensities (WMHs), nigrostriatal dopamine deficits, and cognitive decline in patients with drug-naïve early-stage Parkinson's disease (PD). Method: This cross-sectional study enrolled 309 non-demented patients with de novo PD who underwent [18F] N-(3-fluoropropyl)-2β-carbonethoxy-3β-(4-iodophenyl) nortropane positron emission tomography, brain magnetic resonance imaging, and a detailed neuropsychological test at baseline. We quantified dopamine transporter (DAT) availability in each striatal sub-region and applied the Scheltens scale to assess the severity of periventricular and deep WMHs. The relationships between WMHs, DAT availability, and cognition in PD were assessed using multivariate linear regression and mediation analyses while adjusting for age at parkinsonian symptom onset, sex, disease duration, and vascular risk factors. Results: The severities of periventricular and frontal WMHs were associated with striatal DAT availability. Periventricular WMHs affected the level of cognitive performance in all cognitive domains, while frontal WMHs affected the attention/working memory and frontal/executive function domains. The effects of WMHs on attention/working memory and frontal/executive dysfunction were mostly direct with minimal mediating effects through striatal DAT availability. Meanwhile, striatal DAT availability fully mediated the association between WMHs and cognitive impairment in the visuospatial and memory function domains. Conclusion: This study demonstrated the different effects of WMHs on cognitive impairment depending on the cognitive domains in PD. These findings suggest a close link between comorbid WMHs, striatal dopamine depletion, and cognition in patients with PD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science-
dc.relation.isPartOfPARKINSONISM & RELATED DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCognition-
dc.subject.MESHCognitive Dysfunction* / complications-
dc.subject.MESHCognitive Dysfunction* / etiology-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHDopamine-
dc.subject.MESHDopamine Plasma Membrane Transport Proteins / metabolism-
dc.subject.MESHHumans-
dc.subject.MESHLeukoaraiosis* / pathology-
dc.subject.MESHMagnetic Resonance Imaging / adverse effects-
dc.subject.MESHParkinson Disease* / complications-
dc.subject.MESHParkinson Disease* / diagnostic imaging-
dc.subject.MESHParkinson Disease* / pathology-
dc.subject.MESHWhite Matter* / pathology-
dc.titleAssociations between white matter hyperintensities, striatal dopamine loss, and cognition in drug-naïve Parkinson's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorSeong Ho Jeong-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJin Ho Jung-
dc.contributor.googleauthorKyoungwon Baik-
dc.contributor.googleauthorYoung H Sohn-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1016/j.parkreldis.2022.02.020-
dc.contributor.localIdA01982-
dc.contributor.localIdA03270-
dc.contributor.localIdA03312-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ02468-
dc.identifier.eissn1873-5126-
dc.identifier.pmid35276583-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1353802022000530?via%3Dihub-
dc.subject.keywordCognition-
dc.subject.keywordDopamine transporter-
dc.subject.keywordMediation analysis-
dc.subject.keywordParkinson's disease-
dc.subject.keywordWhite matter hyperintensities-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume97-
dc.citation.startPage1-
dc.citation.endPage7-
dc.identifier.bibliographicCitationPARKINSONISM & RELATED DISORDERS, Vol.97 : 1-7, 2022-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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