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Correlation Between Salivary Microbiome of Parotid Glands and Clinical Features in Primary Sjögren's Syndrome and Non-Sjögren's Sicca Subjects

Authors
 Donghyun Kim  ;  Ye Jin Jeong  ;  Yerin Lee  ;  Jihoon Choi  ;  Young Min Park  ;  Oh Chan Kwon  ;  Yong Woo Ji  ;  Sung Jun Ahn  ;  Hyung Keun Lee  ;  Min-Chan Park  ;  Jae-Yol Lim 
Citation
 FRONTIERS IN IMMUNOLOGY, Vol.13 : 874285, 2022-05 
Journal Title
FRONTIERS IN IMMUNOLOGY
Issue Date
2022-05
MeSH
Biomarkers ; Humans ; Microbiota* ; Parotid Gland ; Salivary Glands / pathology ; Sjogren's Syndrome* / diagnosis ; Sjogren's Syndrome* / pathology
Keywords
Sjögren’s syndrome ; bioinformatics ; microbial diversity ; microbiome ; parotid glands ; saliva
Abstract
Recent studies have demonstrated that the oral microbiome in patients with Sjögren's syndrome (SS) is significantly different from that in healthy individuals. However, the potential role of the oral microbiome in SS pathogenesis has not been determined. In this study, stimulated intraductal saliva samples were collected from the parotid glands (PGs) of 23 SS and nine non-SS subjects through PG lavage and subjected to 16S ribosomal RNA amplicon sequencing. The correlation between the oral microbiome and clinical features, such as biological markers, clinical manifestations, and functional and radiological characteristics was investigated. The salivary microbial composition was examined using bioinformatic analysis to identify potential diagnostic biomarkers for SS. Oral microbial composition was significantly different between the anti-SSA-positive and SSA-negative groups. The microbial diversity in SS subjects was lower than that in non-SS sicca subjects. Furthermore, SS subjects with sialectasis exhibited decreased microbial diversity and Firmicutes abundance. The abundance of Bacteroidetes was positively correlated with the salivary flow rate. Bioinformatics analysis revealed several potential microbial biomarkers for SS at the genus level, such as decreased Lactobacillus abundance or increased Streptococcus abundance. These results suggest that microbiota composition is correlated with the clinical features of SS, especially the ductal structures and salivary flow, and that the oral microbiome is a potential diagnostic biomarker for SS.
Files in This Item:
T202201825.pdf Download
DOI
10.3389/fimmu.2022.874285
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Oh Chan(권오찬)
Kim, Donghyun(김동현) ORCID logo https://orcid.org/0000-0001-7863-7384
Park, Min Chan(박민찬) ORCID logo https://orcid.org/0000-0003-1189-7637
Park, Young Min(박영민) ORCID logo https://orcid.org/0000-0002-7593-8461
Ahn, Sung Jun(안성준) ORCID logo https://orcid.org/0000-0003-0075-2432
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
Lim, Jae Yol(임재열) ORCID logo https://orcid.org/0000-0002-9757-6414
Ji, Yong Woo(지용우) ORCID logo https://orcid.org/0000-0002-7211-6278
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188726
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