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Neural correlates of cricopharyngeal dysfunction after supratentorial stroke: A voxel-based lesion-symptom mapping with propensity score matched case-control

Authors
 Jun Yup Kim  ;  Seo Yeon Yoon  ;  Jinna Kim  ;  Yong Wook Kim 
Citation
 INTERNATIONAL JOURNAL OF STROKE, Vol.17(2) : 207-217, 2022-02 
Journal Title
INTERNATIONAL JOURNAL OF STROKE
ISSN
 1747-4930 
Issue Date
2022-02
MeSH
Case-Control Studies ; Deglutition Disorders* / complications ; Deglutition Disorders* / etiology ; Humans ; Propensity Score ; Retrospective Studies ; Stroke* / complications ; Stroke* / diagnostic imaging ; Stroke* / pathology
Keywords
Supratentorial stroke ; basal ganglia ; cricopharyngeal dysfunction ; dysphagia ; globus pallidus ; lentiform nucleus ; voxel-based lesion-symptom mapping
Abstract
Background: Poststroke cricopharyngeal dysfunction has been reported to occur in 50% of brainstem strokes; however, cricopharyngeal dysfunction also occurs commonly in patients with supratentorial stroke. The hemispheric neuroanatomical location of this dysfunction has not been clearly identified.

Aim: We aimed to analyze the relationship between cricopharyngeal dysfunction and supratentorial lesion location in poststroke patients through this retrospective case-control voxel-based lesion-symptom mapping study.

Methods: Cricopharyngeal dysfunction was diagnosed when the residue after swallowing (pyriform sinus) accounted for more than 25% of volume of pyriform sinus. Medical records and the video fluoroscopic swallowing studies of first-ever stroke patients who were admitted to our hospital during acute to subacute phase from 2009 to 2019 were reviewed. After propensity score matching to reduce the likelihood of selection bias, 50 patients per group were included in the cricopharyngeal dysfunction and control groups. We used a P threshold of 0.01 corrected for multiple comparisons with permutation thresholding (5000 permutations). Dichotomized diagnosis of cricopharyngeal dysfunction and the magnitude of pyriform sinus were used as dependent variables.

Results: Analysis using the Liebermeister statistics indicated that lesions of the right lentiform nucleus were associated with the development of cricopharyngeal dysfunction. After adjustment for age and total lesion volume, which are known effectors for the development of dysphagia, statistically significant correlations were found between pyriform sinus and lesions of the right lentiform nucleus and anterior corona radiata beneath the right middle frontal gyrus.

Conclusion: Thus, our study demonstrated for the first time that damages to the right lentiform nucleus, especially globus pallidus externa, and anterior corona radiata beneath the right middle frontal gyrus are associated with the development and severity of cricopharyngeal dysfunction.
Full Text
https://journals.sagepub.com/doi/10.1177/17474930211006300
DOI
10.1177/17474930211006300
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Wook(김용욱) ORCID logo https://orcid.org/0000-0002-5234-2454
Kim, Jun Yup(김준엽)
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188286
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