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Altered thalamic gray matter volume in firefighters with heavy alcohol use

Authors
 Deokjong Lee  ;  Woojin Kim  ;  Jung Eun Lee  ;  Jung Han Lee  ;  Yun Tae Kim  ;  Seung Koo Lee  ;  Sung Soo Oh  ;  Ki Soo Park  ;  Sang Baek Koh  ;  Changsoo Kim  ;  Young-Chul Jung 
Citation
 DRUG AND ALCOHOL DEPENDENCE, Vol.229(Pt B) : 109099, 2021-12 
Journal Title
DRUG AND ALCOHOL DEPENDENCE
ISSN
 0376-8716 
Issue Date
2021-12
MeSH
Adult ; Brain ; Cerebral Cortex ; Firefighters* ; Gray Matter* / diagnostic imaging ; Humans ; Male ; Middle Aged ; Thalamus
Keywords
Firefighters ; Gray matter volume ; Thalamus ; Voxel-based morphometry
Abstract
Background: Alcohol, a known addictive substance, affects the structural properties of the brain. In this study, we explored associations between alcohol use and gray matter properties among firefighters, who are often exposed to significant occupational stress.

Methods: Gray matter volume (GMV) was evaluated using voxel-based morphometry in 287 male firefighters (mean age: 48.8 ± 7.7 years). Firefighters were classified into 32 never-drinkers, 162 non-heavy alcohol users, and 93 heavy alcohol users according to their alcohol consumption. GMV was compared between groups, and the correlations between GMV and alcohol use were investigated. A voxel-wise height threshold of p < 0.001 (uncorrected) was used, with small volume correction applied on cluster level.

Results: Heavy alcohol users had lower GMV in the bilateral thalamus than non-heavy alcohol users or never-drinkers. Heavy alcohol users also showed lower GMV in the left insula, compared to other groups. The higher the alcohol consumption among firefighters, the lower the GMV of the right thalamus.

Conclusions: The results of this study show that heavy alcohol use has an association with lower GMV in several core regions, including the thalamus. When considering the impact of these brain regions on cognitive and behavioral control, our findings suggest a need for concern about heavy alcohol use among firefighters.
Full Text
https://www.sciencedirect.com/science/article/pii/S0376871621005949
DOI
10.1016/j.drugalcdep.2021.109099
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Woojin(김우진) ORCID logo https://orcid.org/0000-0001-5520-4228
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Lee, Deokjong(이덕종) ORCID logo https://orcid.org/0000-0002-5425-4677
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Jung Eun(이정은)
Lee, Junghan(이정한)
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188168
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