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두경부암의 지방산 대사 표적화

Other Titles
 Targeting Fatty Acid Metabolism in Head and Neck Cancer 
Authors
 김지훈  ;  구민희  ;  양재문  ;  변형권 
Citation
 Korean Journal of Otorhinolaryngology-Head and Neck Surgery, Vol.64(6) : 381-390, 2021-06 
Journal Title
Korean Journal of Otorhinolaryngology-Head and Neck Surgery
ISSN
 2092-5859 
Issue Date
2021-06
Keywords
Energy metabolism ; Head and neck neoplasms ; Lipid metabolism ; Neoplasm invasiveness ; Neoplasm metastasis.
Abstract
Reprogramming of cellular metabolism is an important, emerging, and universal hallmark of
cancer which has received considerable attention during the recent era of cancer research.
Cancer cells show characteristic alterations in glucose metabolism in order to fulfill the needs
of biosynthesis for tumor proliferation and growth. However, under certain circumstances
such as invasion and metastasis, cancer cells are prone to metabolic stress and will require
different strategies to meet the high energetic demand from cancer progression. From various
metabolic rewiring mechanisms, cancer cells adopt other metabolic pathways with alternative
nutrient sources. Therefore, targeting cancer metabolism holds promising but great challenge
caused by the metabolic plasticity of cancer cells. This review will discuss characteristic can cer metabolism in detail with special focus on lipid metabolism which is gathering increasing ly keen interest, in order to find novel therapeutic approaches to head and neck cancer. By un derstanding and exploiting the synthesis, oxidation, and storage of fatty acids, we could
investigate potential strategies to block cancer proliferation and progression.
Files in This Item:
T202125553.pdf Download
DOI
10.3342/kjorl-hns.2021.00066
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Ku, Min Hee(구민희) ORCID logo https://orcid.org/0000-0002-1674-1474
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188129
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