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Association between inflammatory cytokines and caregiving distress in family caregivers of cancer patients

Authors
 Yoonjoo Kim  ;  Heejung Kim  ;  Sang-Yeon Suh  ;  Hyunki Park  ;  Hyangkyu Lee 
Citation
 SUPPORTIVE CARE IN CANCER, Vol.30(2) : 1715-1722, 2022-02 
Journal Title
SUPPORTIVE CARE IN CANCER
ISSN
 0941-4355 
Issue Date
2022-02
MeSH
Caregivers* ; Cross-Sectional Studies ; Cytokines ; Humans ; Neoplasms* ; Stress, Psychological / epidemiology ; Surveys and Questionnaires
Keywords
Cancer ; Caregiver ; Distress ; Inflammatory cytokines
Abstract
Purpose: Caregivers of cancer patients experience distress that can manifest as caregiving burden, burnout, depression, and fatigue. Caregiving distress affects physical health in various ways such as causing the dysregulation of inflammatory functions. We examined the relationships between psychological distress experienced by and inflammatory cytokine levels of family caregivers of cancer patients.

Methods: A descriptive, cross-sectional study involving 93 family caregivers of cancer patients was conducted. Self-report questionnaires were used to measure the distress variables, which included the caregiving burden, burnout, depression, and fatigue, and peripheral blood samples were collected to measure the IL-6, IL-10, and TNF-α levels. Multiple linear regression analyses were conducted to evaluate the impact of caregivers' distress on their inflammatory cytokine levels.

Results: Inflammatory cytokine levels were negatively correlated with caregiving distress. High fatigue levels (B = - 0.047, p = 0.026) and additional days of care provided per week (B = - 0.048, p = 0.009) was associated with low IL-6 levels. High depression levels (B = - 0.250, p = 0.007), high fatigue levels (B = - 0.054, p = 0.027), and more days of care provided per week (B = - 0.048, p = 0.033) were associated with low TNF-α levels. The age of the caregiver (B = - 0.011, p = 0.020) and days of care provided per week (B = - 0.138, p = 0.031) were associated factors for IL-10 levels.

Conclusion: The inflammatory responses were associated with the distress in family caregiving for cancer patients. Thus, interventions are needed to support caregivers and manage their caregiving distress.
Full Text
https://link.springer.com/article/10.1007/s00520-021-06578-y
DOI
10.1007/s00520-021-06578-y
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Kim, Heejung(김희정) ORCID logo https://orcid.org/0000-0003-3719-0111
Lee, Hyang Kyu(이향규) ORCID logo https://orcid.org/0000-0002-0821-6020
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187873
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