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No effect of vitamin D supplementation on metabolic parameters but on lipids in patients with type 2 diabetes and chronic kidney disease

Authors
 Jiwoon Kim  ;  Ji Sun Nam  ;  Heejung Kim  ;  Hye Sun Lee  ;  Jung Eun Lee 
Citation
 INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, Vol.91(5-6) : 649-658, 2021-09 
Journal Title
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
ISSN
 0300-9831 
Issue Date
2021-09
MeSH
Cholecalciferol ; Diabetes Mellitus, Type 2* / complications ; Diabetes Mellitus, Type 2* / drug therapy ; Dietary Supplements ; Humans ; Pulse Wave Analysis ; Renal Insufficiency, Chronic* / complications ; Vitamin D ; Vitamin D Deficiency* / complications ; Vitamin D Deficiency* / drug therapy
Keywords
Diabetes mellitus ; Korea ; chronic kidney disease ; vitamin D deficiency ; vitamin D supplementation
Abstract
Background/Aims: Trials on the effects of cholecalciferol supplementation in type 2 diabetes with chronic kidney disease patients were underexplored. Therefore, the aim of this study was to investigate the effects of two different doses of vitamin D supplementation on serum 25-hydroxyvitamin D [25(OH)D] concentrations and metabolic parameters in vitamin D-deficient Korean diabetes patients with chronic kidney disease. Methods: 92 patients completed this study: the placebo group (A, n = 33), the oral cholecalciferol 1,000 IU/day group (B, n = 34), or the single 200,000 IU injection group (C, n = 25, equivalent to 2,000 IU/day). 52% of the patients had less than 60 mL/min/1.73m2 of glomerular filtration rates. Laboratory test and pulse wave velocity were performed before and after supplementation. Results: After 12 weeks, serum 25(OH)D concentrations of the patients who received vitamin D supplementation were significantly increased (A, -2.4 ± 1.2 ng/mL vs. B, 10.7 ± 1.2 ng/mL vs. C, 14.6 ± 1.7 ng/mL; p < 0.001). In addition, the lipid profiles in the vitamin D injection group (C) showed a significant decrease in triglyceride and a rise in HDL cholesterol. However, the other parameters showed no differences. Conclusions: Our data indicated that two different doses and routes of vitamin D administration significantly and safely increased serum 25(OH)D concentrations in vitamin D-deficient diabetes patients with comorbid chronic kidney disease. In the group that received the higher vitamin D dose, the lipid profiles showed significant improvement, but there were no beneficial effects on other metabolic parameters.
Full Text
https://econtent.hogrefe.com/doi/10.1024/0300-9831/a000642
DOI
10.1024/0300-9831/a000642
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Ji Woon(김지운) ORCID logo https://orcid.org/0000-0002-0169-5030
Kim, Heejung(김희정) ORCID logo https://orcid.org/0000-0002-0190-703X
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187763
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