0 128

Cited 0 times in

Differences and similarities between the upper and lower airway: focusing on innate immunity

Authors
 H-J Cho  ;  J G Ha  ;  S N Lee  ;  C-H Kim  ;  D-Y Wang  ;  J-H Yoon 
Citation
 RHINOLOGY, Vol.59(5) : 441-450, 2021-10 
Journal Title
RHINOLOGY
ISSN
 0300-0729 
Issue Date
2021-10
MeSH
Allergens ; Epithelial Cells ; Immunity, Innate* ; Microbiota* ; Nasal Mucosa
Abstract
The nose is the first respiratory barrier to external pathogens, allergens, pollutants, or cigarette smoke, and vigorous immune responses are triggered when external pathogens come in contact with the nasal epithelium. The mucosal epithelial cells of the nose are essential to the innate immune response against external pathogens and transmit signals that modulate the adaptive immune response. The upper and lower airways share many physiological and immunological features, but there are also numerous differences. It is crucial to understand these differences and their contribution to pathophysiology in order to optimize treatments for inflammatory diseases of the respiratory tract. This review summarizes important differences in the embryological development, histological features, microbiota, immune responses, and cellular subtypes of mucosal epithelial cells of the nose and lungs.
Full Text
https://www.rhinologyjournal.com/Abstract.php?id=2916
DOI
10.4193/Rhin21.046
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Yoon, Joo Heon(윤주헌)
Lee, Sang Nam(이상남)
Cho, Hyung Ju(조형주) ORCID logo https://orcid.org/0000-0002-2851-3225
Ha, Jong Gyun(하종균) ORCID logo https://orcid.org/0000-0002-2712-1297
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187133
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links