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Exacerbation of Mycobacterium avium pulmonary infection by comorbid allergic asthma is associated with diminished mycobacterium-specific Th17 responses

Authors
 Yeeun Bak  ;  Sang Chul Park  ;  Dahee Shim  ;  Yura Ha  ;  Jumi Lee  ;  Hongmin Kim  ;  Kee Woong Kwon  ;  Joo-Heon Yoon  ;  Sung Jae Shin 
Citation
 VIRULENCE, Vol.12(1) : 2546-2561, 2021-12 
Journal Title
VIRULENCE
ISSN
 2150-5594 
Issue Date
2021-12
Keywords
Mycobacterium avium ; Nontuberculous mycobacteria ; Th17 response ; allergic asthma ; chronic respiratory disease ; comorbid diseases ; pathogenesis
Abstract
Accumulating evidence suggests that two chronic respiratory diseases, nontuberculous mycobacterium (NTM)-pulmonary disease (PD) and allergic asthma, are frequently present together and that they likely influence the disease development and progression of each other. However, their precise interactions regarding the pathogenesis of comorbid diseases versus that of individual diseases are not well understood. In this study, comorbid diseases (i.e., Mycobacteria avium (Mav) pulmonary infection (PI) (Mav-PI) and ovalbumin-induced allergic asthma) were established in mice in different orders and at different time periods. Individual disease-specific characteristics, including alterations in immune cell populations and antigen-specific immune responses, were analyzed and compared. To assess Mav-PI pathogenesis, lung inflammation and bacterial burden levels were also determined. Allergic asthma induction in the presence of Mav-PI markedly aggravated Mav-PI pathogenesis by increasing the bacterial burden and the severity of lung inflammation. Interestingly, the general outcome of allergic asthma with goblet cell hyperplasia was alleviated at a chronic stage in the comorbid mouse model. Overall, the increase in the number of Mav CFUs was inversely correlated with the Mav-specific Th17 response, as confirmed by comparing BALB/c and C57BL/6J mice. Overall, the pathogenesis of existing Mav-PI is more severely affected by allergen exposure than vice versa. This Mav-PI exacerbation is associated with disruption of Mav-specific Th17 responses. This study provides the first evidence that the Mav-specific Th17 response plays an important role in the control of Mav pathogenesis in the presence of allergic asthma, indicating that targeting the Th17 response has therapeutic potential for NTM-PD accompanied by allergic asthma.
Files in This Item:
T202105031.pdf Download
DOI
10.1080/21505594.2021.1979812
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Advanced Medical Science Research and Education (첨단의과학교육연구단) > Journal Papers
Yonsei Authors
Kwon, Kee Woong(권기웅)
Shin, Sung Jae(신성재) ORCID logo https://orcid.org/0000-0003-0854-4582
Yoon, Joo Heon(윤주헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187093
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