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The effect of genetic polymorphisms on treatment duration following premolar extraction

 Jiyon Yu  ;  Yoon Jeong Choi  ;  Sung-Hwan Choi  ;  Han-Sung Jung  ;  Ji Hyun Lee  ;  Jung-Yul Cha 
 SCIENTIFIC REPORTS, Vol.11(1) : 15942, 2021-08 
Journal Title
Issue Date
Adolescent ; Adult ; Bicuspid / surgery* ; Case-Control Studies ; Duration of Therapy ; Female ; Gene Expression ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Humans ; Male ; Membrane Proteins / genetics ; Middle Aged ; Orthodontics / methods* ; Osteopontin / genetics ; Polymorphism, Single Nucleotide ; RANK Ligand / genetics ; Receptors, Purinergic P2X7 / genetics ; Retrospective Studies ; Transcriptome ; Treatment Outcome ; Wnt3A Protein / genetics
To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the association of clinical variables with treatment duration was assessed. Patients whose treatment duration deviated from the average were classified into an extreme long group or an extreme short group. We identified nine single nucleotide polymorphisms (SNPs) of six genes that significantly differed in the two groups via targeted sequencing. The frequency of the CC genotypes of WNT3A, SPP1 (rs4754, rs9138), and TNFSF11, TT genotype of SPP1 (rs1126616), and GG genotype of SFRP2 was significantly higher in the extreme long group than in the short group. In the extreme short group, the TC genotype of SPP1, AA genotype of P2RX7, CT genotype of TNFSF11, and AG genotype of TNFRSF11A tended to exhibit higher frequency than in the long group. Taken together, we identified genetic polymorphisms related to treatment duration in Korean orthodontic patients undergoing premolar extraction. Our findings could lead to further studies predicting the prolongation of the orthodontic treatment duration, and will be of great aid to patients as well as orthodontists.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cha, Jung Yul(차정열)
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
Choi, Yoon Jeong(최윤정) ORCID logo https://orcid.org/0000-0003-0781-8836
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