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Indium-111-pentetreotide imaging in intra-axial brain tumors: comparison with thallium-201 SPECT and MRI

Authors
 J D Lee  ;  D I Kim  ;  J T Lee  ;  J W Chang  ;  C Y Park 
Citation
 JOURNAL OF NUCLEAR MEDICINE, Vol.36(4) : 537-541, 1995-04 
Journal Title
JOURNAL OF NUCLEAR MEDICINE
ISSN
 0161-5505 
Issue Date
1995-04
MeSH
Adult ; Aged ; Astrocytoma / chemistry ; Astrocytoma / diagnosis ; Astrocytoma / diagnostic imaging ; Brain Neoplasms / chemistry ; Brain Neoplasms / diagnosis ; Brain Neoplasms / diagnostic imaging* ; Child, Preschool ; Contrast Media ; Diagnosis, Differential ; Female ; Gadolinium DTPA ; Glioblastoma / chemistry ; Glioblastoma / diagnosis ; Glioblastoma / diagnostic imaging ; Humans ; Indium Radioisotopes* ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Organometallic Compounds ; Pentetic Acid / analogs & derivatives ; Prospective Studies ; Receptors, Somatostatin / analysis ; Sensitivity and Specificity ; Somatostatin / analogs & derivatives* ; Thallium Radioisotopes ; Tomography, Emission-Computed, Single-Photon / methods*
Abstract
Highly undifferentiated glial tumors do not express somatostatin receptors (SSR) in contrast to low-grade astrocytomas which contain SSR. To differentiate a malignant glioma from a low-grade astrocytoma and to distinguish an SSR-positive intra-axial brain tumor from an SSR negative one, 111In-pentetreotide brain SPECT was prospectively undertaken.

Methods: Eight patients with intra-axial brain tumors (three glioblastoma multiforme, one low-grade astrocytoma, one lymphoma, one medulloblastoma, one neurocytoma and one metastatic tumor) were studied. Thallium-201 and 111In-pentetreotide brain SPECT were performed with a 3- to 4-day interval before surgery. The SPECT findings were compared with those of Gd-enhanced MRI.

Results: Increased uptake of 111In-pentetreotide was observed in all of the patients with glioblastoma multiforme (Grade in two and Grade + in one) despite lack of SSR. Low-grade astrocytoma exhibited minimal uptake of 111In-pentetreotide (Grade +). Remaining tumors had intense uptake of 111In-pentetreotide. Thallium-201 SPECT showed similar findings to those of 111In-pentetreotide scintigraphy except in two patients with glioblastoma multiforme: One with 201TL negative scan showed increased uptake of 111In-pentetreotide and the other showed increased thallium uptake but minimal uptake of 111In-pentetreotide. The uptake pattern of both 201Tl and 111In-pentetreotide appeared to correlate with Gd-enhanced MRI.

Conclusion: Indium-111-pentetreotide scintigraphy is sensitive in the detection of intra-axial brain tumors; however, it has no role in assessing the tumor grading and in the definition of the receptor profile.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Ik(김동익)
Lee, Jong Doo(이종두)
Lee, Jong Tae(이종태)
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186711
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