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Indium-111-pentetreotide imaging in intra-axial brain tumors: comparison with thallium-201 SPECT and MRI

DC Field Value Language
dc.contributor.author김동익-
dc.contributor.author이종두-
dc.contributor.author이종태-
dc.contributor.author장진우-
dc.date.accessioned2021-12-27T17:31:27Z-
dc.date.available2021-12-27T17:31:27Z-
dc.date.issued1995-04-
dc.identifier.issn0161-5505-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186711-
dc.description.abstractHighly undifferentiated glial tumors do not express somatostatin receptors (SSR) in contrast to low-grade astrocytomas which contain SSR. To differentiate a malignant glioma from a low-grade astrocytoma and to distinguish an SSR-positive intra-axial brain tumor from an SSR negative one, 111In-pentetreotide brain SPECT was prospectively undertaken. Methods: Eight patients with intra-axial brain tumors (three glioblastoma multiforme, one low-grade astrocytoma, one lymphoma, one medulloblastoma, one neurocytoma and one metastatic tumor) were studied. Thallium-201 and 111In-pentetreotide brain SPECT were performed with a 3- to 4-day interval before surgery. The SPECT findings were compared with those of Gd-enhanced MRI. Results: Increased uptake of 111In-pentetreotide was observed in all of the patients with glioblastoma multiforme (Grade in two and Grade + in one) despite lack of SSR. Low-grade astrocytoma exhibited minimal uptake of 111In-pentetreotide (Grade +). Remaining tumors had intense uptake of 111In-pentetreotide. Thallium-201 SPECT showed similar findings to those of 111In-pentetreotide scintigraphy except in two patients with glioblastoma multiforme: One with 201TL negative scan showed increased uptake of 111In-pentetreotide and the other showed increased thallium uptake but minimal uptake of 111In-pentetreotide. The uptake pattern of both 201Tl and 111In-pentetreotide appeared to correlate with Gd-enhanced MRI. Conclusion: Indium-111-pentetreotide scintigraphy is sensitive in the detection of intra-axial brain tumors; however, it has no role in assessing the tumor grading and in the definition of the receptor profile.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherSociety of Nuclear Medicine-
dc.relation.isPartOfJOURNAL OF NUCLEAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAstrocytoma / chemistry-
dc.subject.MESHAstrocytoma / diagnosis-
dc.subject.MESHAstrocytoma / diagnostic imaging-
dc.subject.MESHBrain Neoplasms / chemistry-
dc.subject.MESHBrain Neoplasms / diagnosis-
dc.subject.MESHBrain Neoplasms / diagnostic imaging*-
dc.subject.MESHChild, Preschool-
dc.subject.MESHContrast Media-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHFemale-
dc.subject.MESHGadolinium DTPA-
dc.subject.MESHGlioblastoma / chemistry-
dc.subject.MESHGlioblastoma / diagnosis-
dc.subject.MESHGlioblastoma / diagnostic imaging-
dc.subject.MESHHumans-
dc.subject.MESHIndium Radioisotopes*-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOrganometallic Compounds-
dc.subject.MESHPentetic Acid / analogs & derivatives-
dc.subject.MESHProspective Studies-
dc.subject.MESHReceptors, Somatostatin / analysis-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSomatostatin / analogs & derivatives*-
dc.subject.MESHThallium Radioisotopes-
dc.subject.MESHTomography, Emission-Computed, Single-Photon / methods*-
dc.titleIndium-111-pentetreotide imaging in intra-axial brain tumors: comparison with thallium-201 SPECT and MRI-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorJ D Lee-
dc.contributor.googleauthorD I Kim-
dc.contributor.googleauthorJ T Lee-
dc.contributor.googleauthorJ W Chang-
dc.contributor.googleauthorC Y Park-
dc.contributor.localIdA00408-
dc.contributor.localIdA03138-
dc.contributor.localIdA03150-
dc.contributor.localIdA03484-
dc.relation.journalcodeJ01644-
dc.identifier.eissn1535-5667-
dc.identifier.pmid7699438-
dc.contributor.alternativeNameKim, Dong Ik-
dc.contributor.affiliatedAuthor김동익-
dc.contributor.affiliatedAuthor이종두-
dc.contributor.affiliatedAuthor이종태-
dc.contributor.affiliatedAuthor장진우-
dc.citation.volume36-
dc.citation.number4-
dc.citation.startPage537-
dc.citation.endPage541-
dc.identifier.bibliographicCitationJOURNAL OF NUCLEAR MEDICINE, Vol.36(4) : 537-541, 1995-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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