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Indium-111-pentetreotide imaging in intra-axial brain tumors: comparison with thallium-201 SPECT and MRI
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동익 | - |
dc.contributor.author | 이종두 | - |
dc.contributor.author | 이종태 | - |
dc.contributor.author | 장진우 | - |
dc.date.accessioned | 2021-12-27T17:31:27Z | - |
dc.date.available | 2021-12-27T17:31:27Z | - |
dc.date.issued | 1995-04 | - |
dc.identifier.issn | 0161-5505 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186711 | - |
dc.description.abstract | Highly undifferentiated glial tumors do not express somatostatin receptors (SSR) in contrast to low-grade astrocytomas which contain SSR. To differentiate a malignant glioma from a low-grade astrocytoma and to distinguish an SSR-positive intra-axial brain tumor from an SSR negative one, 111In-pentetreotide brain SPECT was prospectively undertaken. Methods: Eight patients with intra-axial brain tumors (three glioblastoma multiforme, one low-grade astrocytoma, one lymphoma, one medulloblastoma, one neurocytoma and one metastatic tumor) were studied. Thallium-201 and 111In-pentetreotide brain SPECT were performed with a 3- to 4-day interval before surgery. The SPECT findings were compared with those of Gd-enhanced MRI. Results: Increased uptake of 111In-pentetreotide was observed in all of the patients with glioblastoma multiforme (Grade in two and Grade + in one) despite lack of SSR. Low-grade astrocytoma exhibited minimal uptake of 111In-pentetreotide (Grade +). Remaining tumors had intense uptake of 111In-pentetreotide. Thallium-201 SPECT showed similar findings to those of 111In-pentetreotide scintigraphy except in two patients with glioblastoma multiforme: One with 201TL negative scan showed increased uptake of 111In-pentetreotide and the other showed increased thallium uptake but minimal uptake of 111In-pentetreotide. The uptake pattern of both 201Tl and 111In-pentetreotide appeared to correlate with Gd-enhanced MRI. Conclusion: Indium-111-pentetreotide scintigraphy is sensitive in the detection of intra-axial brain tumors; however, it has no role in assessing the tumor grading and in the definition of the receptor profile. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Society of Nuclear Medicine | - |
dc.relation.isPartOf | JOURNAL OF NUCLEAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Astrocytoma / chemistry | - |
dc.subject.MESH | Astrocytoma / diagnosis | - |
dc.subject.MESH | Astrocytoma / diagnostic imaging | - |
dc.subject.MESH | Brain Neoplasms / chemistry | - |
dc.subject.MESH | Brain Neoplasms / diagnosis | - |
dc.subject.MESH | Brain Neoplasms / diagnostic imaging* | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gadolinium DTPA | - |
dc.subject.MESH | Glioblastoma / chemistry | - |
dc.subject.MESH | Glioblastoma / diagnosis | - |
dc.subject.MESH | Glioblastoma / diagnostic imaging | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Indium Radioisotopes* | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Organometallic Compounds | - |
dc.subject.MESH | Pentetic Acid / analogs & derivatives | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Receptors, Somatostatin / analysis | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Somatostatin / analogs & derivatives* | - |
dc.subject.MESH | Thallium Radioisotopes | - |
dc.subject.MESH | Tomography, Emission-Computed, Single-Photon / methods* | - |
dc.title | Indium-111-pentetreotide imaging in intra-axial brain tumors: comparison with thallium-201 SPECT and MRI | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | J D Lee | - |
dc.contributor.googleauthor | D I Kim | - |
dc.contributor.googleauthor | J T Lee | - |
dc.contributor.googleauthor | J W Chang | - |
dc.contributor.googleauthor | C Y Park | - |
dc.contributor.localId | A00408 | - |
dc.contributor.localId | A03138 | - |
dc.contributor.localId | A03150 | - |
dc.contributor.localId | A03484 | - |
dc.relation.journalcode | J01644 | - |
dc.identifier.eissn | 1535-5667 | - |
dc.identifier.pmid | 7699438 | - |
dc.contributor.alternativeName | Kim, Dong Ik | - |
dc.contributor.affiliatedAuthor | 김동익 | - |
dc.contributor.affiliatedAuthor | 이종두 | - |
dc.contributor.affiliatedAuthor | 이종태 | - |
dc.contributor.affiliatedAuthor | 장진우 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 537 | - |
dc.citation.endPage | 541 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUCLEAR MEDICINE, Vol.36(4) : 537-541, 1995-04 | - |
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