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Apparent diffusion coefficient as a prognostic factor in clival chordoma

 Hyeong-Cheol Oh  ;  Chang-Ki Hong  ;  Kyu-Sung Lee  ;  Yoon Jin Cha  ;  Sung Jun Ahn  ;  Sang Hyun Suh  ;  Hun Ho Park 
 SCIENTIFIC REPORTS, Vol.11(1) : 486, 2021-01 
Journal Title
Issue Date
Adult ; Aged ; Chordoma / pathology* ; Chordoma / surgery ; Cranial Fossa, Posterior / pathology* ; Cranial Fossa, Posterior / surgery ; Diffusion Magnetic Resonance Imaging / methods* ; Female ; Humans ; Male ; Middle Aged ; Preoperative Care* ; Prognosis ; ROC Curve ; Retrospective Studies ; Skull Base Neoplasms / pathology* ; Skull Base Neoplasms / surgery ; Survival Rate ; Young Adult
Clival chordoma is a rare disease with high recurrence rates even after a combination of surgical resection and radiotherapy. Apparent diffusion coefficient (ADC) has been used to evaluate aggressive features of chordoma, but its utility for clival chordoma has not been explored specifically. In this study, the utility of preoperative ADC values was analyzed for predicting tumor progression and recurrence in patients with clival chordoma. Between 2012 and 2019, a total of 30 operated cases were analyzed with available preoperative ADC data. Receiver operating characteristic (ROC) analysis was used to obtain ADC cutoff values for predicting tumor aggressiveness. The mean and minimum ADC values were significantly lower in the aggressive tumor group than in the stable tumor group (both P < 0.001). ROC analysis showed that a mean cutoff ADC value of 1198 × 10-6 mm2/s and minimum ADC value of 895.5 × 10-6 mm2/s could be used to predict aggressive features of clival chordoma. Subtotal resection, partial resection, and mean and minimum ADC values that were lower than cutoff values were negative predictors of overall survival and progression-free survival. In conclusion, mean and minimum ADC values could be useful in predicting aggressiveness of clival chordoma.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Sang Hyun(서상현) ORCID logo https://orcid.org/0000-0002-7098-4901
Ahn, Sung Jun(안성준) ORCID logo https://orcid.org/0000-0003-0075-2432
Lee, Kyu Sung(이규성)
Cha, Yoon Jin(차윤진) ORCID logo https://orcid.org/0000-0002-5967-4064
Hong, Chang Ki(홍창기) ORCID logo https://orcid.org/0000-0002-2761-0373
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