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Apparent diffusion coefficient as a prognostic factor in clival chordoma
DC Field | Value | Language |
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dc.contributor.author | 서상현 | - |
dc.contributor.author | 안성준 | - |
dc.contributor.author | 이규성 | - |
dc.contributor.author | 차윤진 | - |
dc.contributor.author | 홍창기 | - |
dc.date.accessioned | 2021-11-19T01:39:16Z | - |
dc.date.available | 2021-11-19T01:39:16Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185965 | - |
dc.description.abstract | Clival chordoma is a rare disease with high recurrence rates even after a combination of surgical resection and radiotherapy. Apparent diffusion coefficient (ADC) has been used to evaluate aggressive features of chordoma, but its utility for clival chordoma has not been explored specifically. In this study, the utility of preoperative ADC values was analyzed for predicting tumor progression and recurrence in patients with clival chordoma. Between 2012 and 2019, a total of 30 operated cases were analyzed with available preoperative ADC data. Receiver operating characteristic (ROC) analysis was used to obtain ADC cutoff values for predicting tumor aggressiveness. The mean and minimum ADC values were significantly lower in the aggressive tumor group than in the stable tumor group (both P < 0.001). ROC analysis showed that a mean cutoff ADC value of 1198 × 10-6 mm2/s and minimum ADC value of 895.5 × 10-6 mm2/s could be used to predict aggressive features of clival chordoma. Subtotal resection, partial resection, and mean and minimum ADC values that were lower than cutoff values were negative predictors of overall survival and progression-free survival. In conclusion, mean and minimum ADC values could be useful in predicting aggressiveness of clival chordoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Chordoma / pathology* | - |
dc.subject.MESH | Chordoma / surgery | - |
dc.subject.MESH | Cranial Fossa, Posterior / pathology* | - |
dc.subject.MESH | Cranial Fossa, Posterior / surgery | - |
dc.subject.MESH | Diffusion Magnetic Resonance Imaging / methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Preoperative Care* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Skull Base Neoplasms / pathology* | - |
dc.subject.MESH | Skull Base Neoplasms / surgery | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Young Adult | - |
dc.title | Apparent diffusion coefficient as a prognostic factor in clival chordoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Hyeong-Cheol Oh | - |
dc.contributor.googleauthor | Chang-Ki Hong | - |
dc.contributor.googleauthor | Kyu-Sung Lee | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Sung Jun Ahn | - |
dc.contributor.googleauthor | Sang Hyun Suh | - |
dc.contributor.googleauthor | Hun Ho Park | - |
dc.identifier.doi | 10.1038/s41598-020-79894-8 | - |
dc.contributor.localId | A01886 | - |
dc.contributor.localId | A02237 | - |
dc.contributor.localId | A02682 | - |
dc.contributor.localId | A04001 | - |
dc.contributor.localId | A04445 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 33436803 | - |
dc.contributor.alternativeName | Suh, Sang Hyun | - |
dc.contributor.affiliatedAuthor | 서상현 | - |
dc.contributor.affiliatedAuthor | 안성준 | - |
dc.contributor.affiliatedAuthor | 이규성 | - |
dc.contributor.affiliatedAuthor | 차윤진 | - |
dc.contributor.affiliatedAuthor | 홍창기 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 486 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.11(1) : 486, 2021-01 | - |
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