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Apparent diffusion coefficient as a prognostic factor in clival chordoma

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dc.contributor.author서상현-
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dc.date.accessioned2021-11-19T01:39:16Z-
dc.date.available2021-11-19T01:39:16Z-
dc.date.issued2021-01-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/185965-
dc.description.abstractClival chordoma is a rare disease with high recurrence rates even after a combination of surgical resection and radiotherapy. Apparent diffusion coefficient (ADC) has been used to evaluate aggressive features of chordoma, but its utility for clival chordoma has not been explored specifically. In this study, the utility of preoperative ADC values was analyzed for predicting tumor progression and recurrence in patients with clival chordoma. Between 2012 and 2019, a total of 30 operated cases were analyzed with available preoperative ADC data. Receiver operating characteristic (ROC) analysis was used to obtain ADC cutoff values for predicting tumor aggressiveness. The mean and minimum ADC values were significantly lower in the aggressive tumor group than in the stable tumor group (both P < 0.001). ROC analysis showed that a mean cutoff ADC value of 1198 × 10-6 mm2/s and minimum ADC value of 895.5 × 10-6 mm2/s could be used to predict aggressive features of clival chordoma. Subtotal resection, partial resection, and mean and minimum ADC values that were lower than cutoff values were negative predictors of overall survival and progression-free survival. In conclusion, mean and minimum ADC values could be useful in predicting aggressiveness of clival chordoma.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHChordoma / pathology*-
dc.subject.MESHChordoma / surgery-
dc.subject.MESHCranial Fossa, Posterior / pathology*-
dc.subject.MESHCranial Fossa, Posterior / surgery-
dc.subject.MESHDiffusion Magnetic Resonance Imaging / methods*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPreoperative Care*-
dc.subject.MESHPrognosis-
dc.subject.MESHROC Curve-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSkull Base Neoplasms / pathology*-
dc.subject.MESHSkull Base Neoplasms / surgery-
dc.subject.MESHSurvival Rate-
dc.subject.MESHYoung Adult-
dc.titleApparent diffusion coefficient as a prognostic factor in clival chordoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorHyeong-Cheol Oh-
dc.contributor.googleauthorChang-Ki Hong-
dc.contributor.googleauthorKyu-Sung Lee-
dc.contributor.googleauthorYoon Jin Cha-
dc.contributor.googleauthorSung Jun Ahn-
dc.contributor.googleauthorSang Hyun Suh-
dc.contributor.googleauthorHun Ho Park-
dc.identifier.doi10.1038/s41598-020-79894-8-
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dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
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dc.contributor.alternativeNameSuh, Sang Hyun-
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dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage486-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.11(1) : 486, 2021-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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