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Clinical and Immunological Efficacy of Mangosteen and Propolis Extracted Complex in Patients with Gingivitis: A Multi-Centered Randomized Controlled Clinical Trial

 Jin-Young Park  ;  Kyung-A Ko  ;  Ji-Yeong Lee  ;  Jae-Woon Oh  ;  Hyun-Chang Lim  ;  Dong-Woon Lee  ;  Seong-Ho Choi  ;  Jae-Kook Cha 
 NUTRIENTS, Vol.13(8) : 2604, 2021-07 
Journal Title
Issue Date
Adult ; Aged ; Biomarkers ; Female ; Garcinia mangostana / chemistry* ; Gingivitis / drug therapy* ; Humans ; Interleukin-6 ; Male ; Matrix Metalloproteinase 9 ; Middle Aged ; Periodontal Index ; Periodontitis / drug therapy ; Plant Extracts / therapeutic use* ; Propolis / therapeutic use* ; Saliva ; Surveys and Questionnaires ; Young Adult
gingivitis ; mangosteen ; propolis
Background: Mangosteen and propolis extracts (MAEC) have been potential therapeutic agents known to exhibit powerful antioxidant and anti-inflammatory properties. The aim of the current study was to evaluate the clinical and immunological efficacy of MAEC as well as safety and patient-reported outcomes (PROMs) on gingivitis and incipient periodontitis.

Methods: This study was performed on 104 patients diagnosed with gingivitis or incipient periodontitis. At baseline, the participants were randomly allocated to either the test group, with daily intake of a single capsule containing 194 mg of MAEC for eight weeks, or control group, with placebo. Clinical periodontal evaluation and immunological parameters from saliva and gingival sulcular fluid were assessed at baseline, four, and eight weeks. Individual PROMs were assessed by OHIP-14 questionnaires.

Results: There was a significant difference of modified gingival index at four and eight weeks between the test and control groups. In the test group, crevicular interleukin (IL)-6 was reduced, and the salivary matrix metalloproteinase (MMP)-9 was increased after eight weeks. PROMs were improved up to four weeks compared to placebo.

Conclusion: Oral administration of MAEC would have a potential to reduce gingival inflammation clinically and immunologically in the patients with gingivitis and incipient periodontitis.
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2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jin Young(박진영)
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
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