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Cardiovascular disease burden in adult patients with cancer: An 11-year nationwide population-based cohort study

Authors
 Jong-Chan Youn  ;  Woo-Baek Chung  ;  Justin A Ezekowitz  ;  Jung Hwa Hong  ;  Hyewon Nam  ;  Dae-Sung Kyoung  ;  In-Cheol Kim  ;  Alexander R Lyon  ;  Seok-Min Kang  ;  Hae Ok Jung  ;  Kiyuk Chang  ;  Yong-Seog Oh  ;  Ho-Joong Youn  ;  Sang Hong Baek  ;  Hyeon Chang Kim 
Citation
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.317 : 167-173, 2021-10 
Journal Title
INTERNATIONAL JOURNAL OF CARDIOLOGY
ISSN
 0167-5273 
Issue Date
2021-10
MeSH
Adult ; Cardiovascular Diseases* / diagnosis ; Cardiovascular Diseases* / epidemiology ; Cohort Studies ; Diabetes Mellitus* ; Humans ; Male ; Neoplasms* / diagnosis ; Neoplasms* / epidemiology ; Prevalence ; Risk Factors
Keywords
Cancer ; Cardiovascular disease burden ; Mortality ; Population-based cohort
Abstract
Background: Cardiovascular disease (CVD) is an important cause of morbidity and mortality in patients with cancer. However, the real-world CVD burden of adult cancer patients has not been well established. This study aimed to evaluate the prevalence and mortality of pre-existing and new-onset CVD in patients with cancers. Methods: We analysed the prevalence and mortality of pre-existing and new-onset CVD in 41,034 adult patients with ten common solid cancers in a single payer system using data from the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Results: When all types of cancer were included, 11.3% (n = 4647) of patients had pre-existing CVD when they were diagnosed with cancer. After excluding patients with pre-existing CVD, 15.7% of cancer patients (n = 5703) were newly diagnosed with CVD during the follow-up period (median 68 months). Both pre-existing and new-onset CVD were associated with increased risk of overall mortality and 5-year mortality. Multivariate analysis to predict all-cause mortality indicated both pre-existing and new-onset CVD, male sex, old age, prior history of diabetes or chronic kidney disease, suburban residential area, and low-income status as significant factors. Conclusions: Eleven percent of cancer patients had pre-existing CVD at the time of cancer diagnosis, and about 16% of cancer patients without pre-existing CVD were newly diagnosed with CVD, mostly within 5 years after the cancer diagnosis. Proper management of pre-existing CVD is necessary and pre-emptive prevention of new-onset CVD may alter treatment options and outcomes.
Full Text
https://www.sciencedirect.com/science/article/pii/S0167527320302606
DOI
10.1016/j.ijcard.2020.04.080
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185368
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